Therapy of Sinonasal Microbiome in CRS: A Critical Approach

Therapy of Sinonasal Microbiome in CRS: A Critical Approach Curr Allergy Asthma Rep (2017) 17:59 DOI 10.1007/s11882-017-0726-x RHINOSINUSITIS (J MULLOL, SECTION EDITOR) 1 1 Alkis J. Psaltis & Peter-John Wormald Springer Science+Business Media, LLC 2017 . . Abstract Keywords Microbiota Sinonasal microbiome Microbial Purpose of Review Perturbations in local microbiota have dysbiosis Chronic rhinosinusitis been demonstrated in many chronic inflammatory diseases including chronic rhinosinusitis (CRS). The purpose of this paper is to review the latest microbiome research as it pertains Introduction to CRS and establish whether there is any evidence supporting the microbiome hypothesis for CRS. Treatment factors that Microbiota are ecological communities of commensal, sym- may influence the sinonasal microbiome as well as the role biotic and pathogenic microorganisms, found in and on all of probiotics are also discussed. multicellular organisms. Advances in culture independent de- Recent Findings Despite significant heterogeneity in study tection techniques have allowed us to better characterize and design, tissue sampling, processing and bioinformatics analy- evaluate the local microbiota at all human surfaces. The mi- sis, consistent findings have emerged from the recent litera- crobiota is a significant source of both nutritional metabolites ture. Healthy individuals and CRS patients have similar over- and inflammatory immune signals, and therefore it is pro- all bacterial Current Allergy and Asthma Reports Springer Journals

Therapy of Sinonasal Microbiome in CRS: A Critical Approach

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Copyright © 2017 by Springer Science+Business Media, LLC
Medicine & Public Health; Allergology
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