Therapy assessment of bone metastatic disease in the era of 223radium

Therapy assessment of bone metastatic disease in the era of 223radium Eur J Nucl Med Mol Imaging (2017) 44 (Suppl 1):S84–S96 DOI 10.1007/s00259-017-3734-0 REVIEW ARTICLE Therapy assessment of bone metastatic disease in the era of radium 1 1 2 2 Elba Etchebehere & Ana Emilia Brito & Alireza Rezaee & Werner Langsteger & 2,3 Mohsen Beheshti Received: 10 May 2017 /Accepted: 12 May 2017 /Published online: 31 May 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract Introduction Purpose Defining an optimal imaging modality for assess- ment of therapy and the best time of evaluation are pivotal Prostate cancer is the second most common cancer among for ideal patient’smanagement. men and the sixth leading cause of cancer-related death world- Methods Ra (Xofigo®, formerly Alpharadin) has been ap- wide [1]. It metastasizes to skeleton in approximately 65–75% proved by the FDA and European Medicines Agency for treat- of cases, which dramatically changes the outcome in these ment of metastatic castration-resistant prostate cancer with patients [2, 3]. To avoid related morbidities such as bone pain, painful osseous involvement. bone fracture and possible cord compression, it is crucial to Results PET/CT imaging using various radiotracers such as discover and manage the lesions early in the course of meta- 18 18 68 18 F–FDG, F–FCH, Ga-PSMA and European Journal of Nuclear Medicine and Molecular Imaging Springer Journals

Therapy assessment of bone metastatic disease in the era of 223radium

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Medicine & Public Health; Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology
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