Purpose of review The purpose of this review was to discuss the currently available pharmacologic and non-pharmacologic treatment options for parasomnias. Recent findings Recent pathophysiological findings about sleep structure in parasomnias helped understanding several drug mechanisms of action. Serotoninergic theory accounts for the effect of serotoninergic drugs. Study about spectral analysis of sleep showed the effect of clonazepam on spectral bands. Cannabinoids proved to be effective in some of parasomnias, as in many other neurological disorders. Summary A series of therapeutic strategies were analyzed and compared. Benzodiaze- pines, antidepressant drugs, and L-5-hydroxytryptophan may be beneficial in DOA. SSRI and topiramate are effective in SRED. RBD responds to clonazepam, melatonin, and to a lesser extent to dopaminergic and anticholinergic agents. Prazosin and cannabinoids are effective in nightmare disorder. Sleep paralysis may respond to antidepressant agents. Tricyclic antidepressant may be effective in sleep-related hallucinations and exploding head syndrome. Sleep enuresis may be successfully treated with desmopressin, anticho- linergic drugs, and imipramine. Introduction Parasomnias are disorders characterized by complex On the basis of the sleep stage the parasomnias arise motor or behavioral events that occur during entry into from, they are classified as follows: NREM-related sleep, within sleep, or during arousal from
Current Treatment Options in Neurology – Springer Journals
Published: Jun 5, 2018
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