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R. Manian, J. Jayashankaran, S. Kumar, R. Raghunathan (2006)
A novel entry to dispiropyrrolo-bicyclo[2.2.1]heptanes through sequential 1,3-dipolar and Diels–Alder cycloaddition reactionsTetrahedron Letters, 47
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Solution phase synthesis of a spiro[pyrrolidine-2,3′-oxindole] library via a three component 1,3-dipolar cycloaddition reactionTetrahedron Letters, 39
A. Raj, R. Raghunathan, M.R SrideviKumari, N. Raman (2003)
Synthesis, antimicrobial and antifungal activity of a new class of spiro pyrrolidines.Bioorganic & medicinal chemistry, 11 3
Gang Chen, Jing Yang, Suo Gao, Hongping He, Shun-Lin Li, Y. Di, Ying Chang, Yang Lu, X. Hao (2011)
Spiro[pyrrolidine-2,3′-oxindole] derivatives synthesized by novel regionselective 1,3-dipolar cycloadditionsMolecular Diversity, 16
Gang Chen, Jing Yang, Suo Gao, Yu Zhang, X. Hao (2013)
Theoretical study of the regioselectivity of the Huisgen reactionResearch on Chemical Intermediates, 39
R. Pardasani, P. Pardasani, V. Chaturvedi, S. Yadav, A. Saxena, I. Sharma (2003)
Theoretical and synthetic approach to novel spiroheterocycles derived from isatin derivatives and L‐proline via 1,3‐dipolar cycloadditionHeteroatom Chemistry, 14
Gang Chen, Ya Wu, Xuefang Gu (2011)
Spiro indane-1,3-dione pyrrolizidine compounds synthesized by 1,3-dipolar cyclo-addition reaction, 17
A. El-ahl (2002)
Three‐component 1,3‐dipolar cycloaddition reactions in synthesis of spiro[pyrrolidine‐2,3′‐oxindoline] derivativesHeteroatom Chemistry, 13
Gang Chen, Hong He, Jia-Yin Ding, X. Hao (2009)
Synthesis and Antitumor Activity Evaluation of Regioselective Spiro [pyrrolidine-2,3'-oxindole] CompoundsHeterocyclic Communications, 15
R. Huisgen (1963)
Kinetics and Mechanism of 1,3‐Dipolar CycloadditionsAngewandte Chemie, 2
Study of the structures of a series of spiro [pyrrolidine-2,3′-oxindole] derivatives synthesized by [3+2] cycloaddition reaction of isatin, α-amino acids, and β-substituted phenylethylenes revealed the regioselectivity of the reaction was completely novel. The reaction mechanism for [3+2] cycloaddition of oxindole azomethine ylide and the β-substituted phenylethylenes was calculated by use of density functional theory with the B3LYP functional and different basis sets. The results show that the regioselectivity of this [3+2] cycloaddition reaction is kinetically controlled, which agrees with experimental results.
Research on Chemical Intermediates – Springer Journals
Published: Mar 27, 2014
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