Study of the structures of a series of spiro [pyrrolidine-2,3′-oxindole] derivatives synthesized by [3+2] cycloaddition reaction of isatin, α-amino acids, and β-substituted phenylethylenes revealed the regioselectivity of the reaction was completely novel. The reaction mechanism for [3+2] cycloaddition of oxindole azomethine ylide and the β-substituted phenylethylenes was calculated by use of density functional theory with the B3LYP functional and different basis sets. The results show that the regioselectivity of this [3+2] cycloaddition reaction is kinetically controlled, which agrees with experimental results.
Research on Chemical Intermediates – Springer Journals
Published: Mar 27, 2014
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