Theoretical Calculation of Bending Stiffness of Alveolar Wall

Theoretical Calculation of Bending Stiffness of Alveolar Wall The bending stiffness of the alveolar wall is theoretically analyzed in this study through analytical modeling. First, the alveolar wall facet and its characteristics were geometrically simplified and then modeled using known physical laws. Bending stiffness is shown to be dependent on alveolar wall thickness, density, Poisson’s ratio and speed of the longitudinal wave. The normal bending stiffness of the alveolar wall was further determined. For the adult human, the normal bending stiffness is calculated to be 71.0–414.7 nNm, while for the adult mouse it is 1.9–30.0 nNm. The results of this study can be used as a reference for future pulmonary emphysema and fibrosis studies, as the bending stiffness of alveolar wall will be lower and higher, respectively; than the theoretically determined normal values. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Theoretical Calculation of Bending Stiffness of Alveolar Wall

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Publisher
Springer US
Copyright
Copyright © 2013 by Springer Science+Business Media New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s00232-013-9602-3
Publisher site
See Article on Publisher Site

Abstract

The bending stiffness of the alveolar wall is theoretically analyzed in this study through analytical modeling. First, the alveolar wall facet and its characteristics were geometrically simplified and then modeled using known physical laws. Bending stiffness is shown to be dependent on alveolar wall thickness, density, Poisson’s ratio and speed of the longitudinal wave. The normal bending stiffness of the alveolar wall was further determined. For the adult human, the normal bending stiffness is calculated to be 71.0–414.7 nNm, while for the adult mouse it is 1.9–30.0 nNm. The results of this study can be used as a reference for future pulmonary emphysema and fibrosis studies, as the bending stiffness of alveolar wall will be lower and higher, respectively; than the theoretically determined normal values.

Journal

The Journal of Membrane BiologySpringer Journals

Published: Oct 12, 2013

References

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