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Theophylline

Theophylline Reactions 1704, p358 - 2 Jun 2018 Theophylline toxicity: case report A 4-year-old girl developed vomiting, diarrhoea, decreased response, focal seizures, hypokalaemia, hyperglycaemia, respiratory acidosis, metabolic acidosis, sinus tachycardia and respiratory failure following exploratory ingestion of theophylline [amount of drug ingested not stated]. The girl presented to the emergency department for vomiting and diarrhoea, persisting for several hours. She was diagnosed with urinary tract infection and was discharged on cotrimoxazole [trimethoprim/sulfamethoxazole] and treatment. She returned to the emergency department again and was found to be unresponsive, with a heart rate of 170 bpm, blood pressure of 82/46mm Hg and a respiratory rate of 40 breaths/minute. She also developed seizures. She was afebrile, however, laboratory tests were consistent with hypokalaemia, elevated creatinine, hyperglycaemia, metabolic acidosis and respiratory acidosis. Tests for the presence of various medications and drug abuse were absent. Her ECG revealed sinus tachycardia with QRS widening and QTc prolongation. A head CT did not show any abnormalities. Subsequently, her sibling revealed that the previous morning, she had ingested her father’s 200mg sustained-release theophylline tablets. Her theophylline level was ordered, which was significantly elevated. Her clinical condition declined and she was intubated due to respiratory failure. The girl started http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Theophylline

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Theophylline

Abstract

Reactions 1704, p358 - 2 Jun 2018 Theophylline toxicity: case report A 4-year-old girl developed vomiting, diarrhoea, decreased response, focal seizures, hypokalaemia, hyperglycaemia, respiratory acidosis, metabolic acidosis, sinus tachycardia and respiratory failure following exploratory ingestion of theophylline [amount of drug ingested not stated]. The girl presented to the emergency department for vomiting and diarrhoea, persisting for several hours. She was diagnosed with urinary tract...
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References (1)

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-47001-8
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p358 - 2 Jun 2018 Theophylline toxicity: case report A 4-year-old girl developed vomiting, diarrhoea, decreased response, focal seizures, hypokalaemia, hyperglycaemia, respiratory acidosis, metabolic acidosis, sinus tachycardia and respiratory failure following exploratory ingestion of theophylline [amount of drug ingested not stated]. The girl presented to the emergency department for vomiting and diarrhoea, persisting for several hours. She was diagnosed with urinary tract infection and was discharged on cotrimoxazole [trimethoprim/sulfamethoxazole] and treatment. She returned to the emergency department again and was found to be unresponsive, with a heart rate of 170 bpm, blood pressure of 82/46mm Hg and a respiratory rate of 40 breaths/minute. She also developed seizures. She was afebrile, however, laboratory tests were consistent with hypokalaemia, elevated creatinine, hyperglycaemia, metabolic acidosis and respiratory acidosis. Tests for the presence of various medications and drug abuse were absent. Her ECG revealed sinus tachycardia with QRS widening and QTc prolongation. A head CT did not show any abnormalities. Subsequently, her sibling revealed that the previous morning, she had ingested her father’s 200mg sustained-release theophylline tablets. Her theophylline level was ordered, which was significantly elevated. Her clinical condition declined and she was intubated due to respiratory failure. The girl started

Journal

Reactions Weekly – Springer Journals

Published: Jun 2, 2018

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