The VEGF-A inhibitor sFLT-1 improves renal function by reducing endothelial activation and inflammation in a mouse model of type 1 diabetes

The VEGF-A inhibitor sFLT-1 improves renal function by reducing endothelial activation and... Diabetologia (2017) 60:1813–1821 DOI 10.1007/s00125-017-4322-3 ARTICLE The VEGF-A inhibitor sFLT-1 improves renal function by reducing endothelial activation and inflammation in a mouse model of type 1 diabetes 1 1 1 2 Pascal Bus & Marion Scharpfenecker & Priscilla Van Der Wilk & Ron Wolterbeek & 1 1 Jan A. Bruijn & Hans J. Baelde Received: 15 February 2017 /Accepted: 9 May 2017 /Published online: 15 June 2017 The Author(s) 2017. This article is an open access publication Abstract control mice (n = 5); non-diabetic control mice transfected Aims/hypothesis Animal models of diabetic nephropathy with sFlt-1(n = 10); and non-transfected diabetic mice show increased levels of glomerular vascular endothelial (n = 6). These mice were euthanised at the end of week 15. growth factor (VEGF)-A, and several studies have shown that Transfection with sFlt-1 was performed in week 6. inhibiting VEGF-A in animal models of diabetes can prevent Results We found that transfection with sFlt-1 significantly albuminuria and glomerular hypertrophy. However, in those reduced kidney damage by normalising albuminuria, glomer- studies, treatment was initiated before the onset of kidney ular hypertrophy and mesangial matrix content (i.e. glomeru- damage. Therefore, the aim of this study was to investigate lar collagen type http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

The VEGF-A inhibitor sFLT-1 improves renal function by reducing endothelial activation and inflammation in a mouse model of type 1 diabetes

Loading next page...
 
/lp/springer_journal/the-vegf-a-inhibitor-sflt-1-improves-renal-function-by-reducing-4bDj4xcRFV
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by The Author(s)
Subject
Medicine & Public Health; Internal Medicine; Metabolic Diseases; Human Physiology
ISSN
0012-186X
eISSN
1432-0428
D.O.I.
10.1007/s00125-017-4322-3
Publisher site
See Article on Publisher Site

Abstract

Diabetologia (2017) 60:1813–1821 DOI 10.1007/s00125-017-4322-3 ARTICLE The VEGF-A inhibitor sFLT-1 improves renal function by reducing endothelial activation and inflammation in a mouse model of type 1 diabetes 1 1 1 2 Pascal Bus & Marion Scharpfenecker & Priscilla Van Der Wilk & Ron Wolterbeek & 1 1 Jan A. Bruijn & Hans J. Baelde Received: 15 February 2017 /Accepted: 9 May 2017 /Published online: 15 June 2017 The Author(s) 2017. This article is an open access publication Abstract control mice (n = 5); non-diabetic control mice transfected Aims/hypothesis Animal models of diabetic nephropathy with sFlt-1(n = 10); and non-transfected diabetic mice show increased levels of glomerular vascular endothelial (n = 6). These mice were euthanised at the end of week 15. growth factor (VEGF)-A, and several studies have shown that Transfection with sFlt-1 was performed in week 6. inhibiting VEGF-A in animal models of diabetes can prevent Results We found that transfection with sFlt-1 significantly albuminuria and glomerular hypertrophy. However, in those reduced kidney damage by normalising albuminuria, glomer- studies, treatment was initiated before the onset of kidney ular hypertrophy and mesangial matrix content (i.e. glomeru- damage. Therefore, the aim of this study was to investigate lar collagen type

Journal

DiabetologiaSpringer Journals

Published: Jun 15, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off