The Value of the C-Reactive Protein-to-Albumin Ratio is Useful for Predicting Survival of Patients with Child–Pugh Class A Undergoing Liver Resection for Hepatocellular Carcinoma

The Value of the C-Reactive Protein-to-Albumin Ratio is Useful for Predicting Survival of... Background Although a recent study has shown that the C-reactive protein-to-albumin ratio (CAR) can predict the survival in patients with hepatocellular carcinoma (HCC), it is unclear whether CAR can predict the survival after surgery. Objective To investigate the utility of CAR for prediction of postoperative survival among HCC patients with Child– Pugh class A. Methods We retrospectively reviewed 239 patients with Child–Pugh class A who were newly diagnosed with HCC and received initial liver resection. Univariate and multivariate analyses using the Cox proportional hazard model were performed to detect clinical characteristics that correlated with overall survival (OS), and their cutoff values were identified using receiver operating characteristic curve analyses. The cutoff value of CAR was 0.028. Kaplan– Meier analysis and the log-rank test were used for the comparison of OS and disease-free survival (DFS) between two CAR groups ([0.028/B0.028). Results Multivariate analysis using 16 clinical characteristics selected by univariate analyses revealed that CAR ([0.028/B0.028) (HR, 3.211; 95% CI 1.065–9.680; P = 0.038) was significantly associated with OS, as well as anatomical resection (presence/absence) (HR, 0.275; 95% CI 0.119–0.635; P = 0.275). A significant difference in OS and DFS was observed between patients with low CAR (B0.028) and patients with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png World Journal of Surgery Springer Journals

The Value of the C-Reactive Protein-to-Albumin Ratio is Useful for Predicting Survival of Patients with Child–Pugh Class A Undergoing Liver Resection for Hepatocellular Carcinoma

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Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Société Internationale de Chirurgie
Subject
Medicine & Public Health; Surgery; Abdominal Surgery; Cardiac Surgery; General Surgery; Thoracic Surgery; Vascular Surgery
ISSN
0364-2313
eISSN
1432-2323
D.O.I.
10.1007/s00268-017-4446-0
Publisher site
See Article on Publisher Site

Abstract

Background Although a recent study has shown that the C-reactive protein-to-albumin ratio (CAR) can predict the survival in patients with hepatocellular carcinoma (HCC), it is unclear whether CAR can predict the survival after surgery. Objective To investigate the utility of CAR for prediction of postoperative survival among HCC patients with Child– Pugh class A. Methods We retrospectively reviewed 239 patients with Child–Pugh class A who were newly diagnosed with HCC and received initial liver resection. Univariate and multivariate analyses using the Cox proportional hazard model were performed to detect clinical characteristics that correlated with overall survival (OS), and their cutoff values were identified using receiver operating characteristic curve analyses. The cutoff value of CAR was 0.028. Kaplan– Meier analysis and the log-rank test were used for the comparison of OS and disease-free survival (DFS) between two CAR groups ([0.028/B0.028). Results Multivariate analysis using 16 clinical characteristics selected by univariate analyses revealed that CAR ([0.028/B0.028) (HR, 3.211; 95% CI 1.065–9.680; P = 0.038) was significantly associated with OS, as well as anatomical resection (presence/absence) (HR, 0.275; 95% CI 0.119–0.635; P = 0.275). A significant difference in OS and DFS was observed between patients with low CAR (B0.028) and patients with

Journal

World Journal of SurgerySpringer Journals

Published: Dec 29, 2017

References

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