Short Communications Incorporating Mouse Genome Mammalian Genome 11, 461–463 (2000). © Springer-Verlag New York Inc. 2000 The upstream region of the mouse Xist gene contains two ribosomal protein pseudogenes Justyna T. Romer, Alan Ashworth The Breakthrough Toby Robins Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK Received: 11 November 1999 / Accepted: 25 January 2000 The difference in dosage of X-linked genes between XX females trons, indicates that the S12-like sequence is most likely a pseu- and XY males in mammals is equalized by inactivation of one X dogene. This region of sequence similarity with S12 mRNA ends Chromosome (Chr) in every female somatic cell (reviewed by in an AT-rich sequence. This is a typical feature of processed Lyon 1992). The X inactivation center, Xic, is required for X Chr pseudogenes, which arise via an mRNA intermediate, and thus counting and the initiation of X-inactivation, and the Xist gene, have features of a processed transcript (Rogers 1985). The stretch which maps to the Xic locus, has been proposed to function as the of AT base pairs is thought to correspond to the polyA tail of the Xic (reviewed by Brockdorff 1998). Deletion
Mammalian Genome – Springer Journals
Published: Feb 5, 2014
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