Rheumatology International (2018) 38:531–533 Rheumatology https://doi.org/10.1007/s00296-017-3896-x INTERNATIONAL CORRESPONDENCE The TT genotype of the rs6860 polymorphism of the charged multivesicular body protein 1A gene is associated with susceptibility to fibromyalgia in southern Spanish women 1,2 3 4 5 Fernando Estévez‑López · Virginia A. Aparicio · Jonatan R. Ruiz · Luis J. Martínez‑González · 1 5,6 Manuel Delgado‑Fernández · María J. Álvarez‑Cubero Received: 5 October 2017 / Accepted: 26 November 2017 / Published online: 15 December 2017 © Springer-Verlag GmbH Germany, part of Springer Nature 2017 In 2012, Barbosa et al.  analysed the association between rs6860 polymorphism were more frequent in the case group the genotype frequencies of the rs4680 and rs4818 polymor- compared to the control group (Table 1). Additionally, the phisms of the catechol-O-methyltransferase (COMT) gene. level of pain in the past 7 days was assessed with the revised Of note is that, in the abstract, they mentioned the rs6860 fibromyalgia impact questionnaire [2 ]. One-way analysis of polymorphism when it should have been rs4680. Indeed, the variance indicated that, in fibromyalgia, pain was similar for rs6860 polymorphism is not part of the COMT gene. all the genotypes of the rs4680, rs4818, and rs6860 polymor- The rs4680 and rs4818 polymorphisms are related to phisms (p = 0.41, 0.47, and 0.60, respectively). the COMT gene, which is the most
Rheumatology International – Springer Journals
Published: Dec 15, 2017
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