Brief Data Reports Mammalian Genome 8, 157-160 (1997). 9 Springer-Verlag New York Inc. 1997 For Edn2 to be considered as a valid candidate gene for being the Structure and organization of the rat blood pressure QTL on rat Chr 5, there would have to be a sig- Endothelin-2 gene nificant nucleotide difference(s) between the Edn2 gene of the S rat and the Edn2 gene of the LEW rat. This difference(s) would be Alan Y. Deng such that it could cause the differing Edn2 genes of the S and LEW rats to function differently. Department of Physiology and Molecular Medicine, Block Health In the current work, there are no significant nucleotide differ- Science Building, Room 320, Me&cal College of Ohio, P.O. Box ences between the S and LEW rats detected in the region of Edn2 10008, Toledo, Ohio 43699-0008, USA genes that are potentially important in the Edn2 function. As a consequence, the Edn2 gene per se is not supported as a candidate Received: 5 June 1996 / Accepted: 4 October 1996 QTL causing a blood pressure difference between the S and LEW rats . The present sequence data alone, however, do not, and Species: Rat (Rattus norvegicus) cannot, rule
Mammalian Genome – Springer Journals
Published: Mar 24, 2009
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