The synergic effect of the E298D polymorphism of the endothelial nitric oxide synthase gene and smoking status on the risk of cerebral stroke

The synergic effect of the E298D polymorphism of the endothelial nitric oxide synthase gene and... Violations of the endothelium-dependent regulation of cerebral vessel tone are an important link in the pathogenesis of cerebrovascular disorders. The purpose of this study was to investigate the association of −786T>C and E298D polymorphisms of the endothelial nitric oxide synthase (NOS3) gene with the risk of cerebral stroke (CS) in Russian inhabitants of Central Russia, as well as to evaluate the trigger effect of smoking on the risk of CS in carriers of genotypes NOS3. Genotyping of −786T>C and E298D polymorphisms of the NOS3 gene was carried out in 480 CS patients and 424 almost healthy volunteers using real time PCR and TaqMan allele discrimination assays. It was determined that the genotype 298DD is associated with the risk of CS (OR = 1.71, 95% CI = 1.05–2.78, P = 0.03). Subsequent analysis showed that genotype 298DD (OR = 3.75; 95% CI = 1.39–10.11; P = 0.01) is associated with an increased risk of CS exclusively in smoking individuals. The combination of genotypes −786T/C × 298D/D was associated with the risk of CS in smokers (OR = 7.71; 95% CI = 1.31–45.34; P = 0.02). In the present study, it was found that smoking status is a significant modifying risk factor for cerebral stroke in the carriers of the 298DD and −786T/C genotypes of endothelial nitric oxide synthase. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

The synergic effect of the E298D polymorphism of the endothelial nitric oxide synthase gene and smoking status on the risk of cerebral stroke

Loading next page...
 
/lp/springer_journal/the-synergic-effect-of-the-e298d-polymorphism-of-the-endothelial-QATHjvmWr8
Publisher
Pleiades Publishing
Copyright
Copyright © 2015 by Pleiades Publishing, Inc.
Subject
Biomedicine; Human Genetics; Animal Genetics and Genomics; Microbial Genetics and Genomics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1134/S1022795415020052
Publisher site
See Article on Publisher Site

Abstract

Violations of the endothelium-dependent regulation of cerebral vessel tone are an important link in the pathogenesis of cerebrovascular disorders. The purpose of this study was to investigate the association of −786T>C and E298D polymorphisms of the endothelial nitric oxide synthase (NOS3) gene with the risk of cerebral stroke (CS) in Russian inhabitants of Central Russia, as well as to evaluate the trigger effect of smoking on the risk of CS in carriers of genotypes NOS3. Genotyping of −786T>C and E298D polymorphisms of the NOS3 gene was carried out in 480 CS patients and 424 almost healthy volunteers using real time PCR and TaqMan allele discrimination assays. It was determined that the genotype 298DD is associated with the risk of CS (OR = 1.71, 95% CI = 1.05–2.78, P = 0.03). Subsequent analysis showed that genotype 298DD (OR = 3.75; 95% CI = 1.39–10.11; P = 0.01) is associated with an increased risk of CS exclusively in smoking individuals. The combination of genotypes −786T/C × 298D/D was associated with the risk of CS in smokers (OR = 7.71; 95% CI = 1.31–45.34; P = 0.02). In the present study, it was found that smoking status is a significant modifying risk factor for cerebral stroke in the carriers of the 298DD and −786T/C genotypes of endothelial nitric oxide synthase.

Journal

Russian Journal of GeneticsSpringer Journals

Published: Mar 6, 2015

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off