The surrounding environments on the structure and antioxidative activity of luteolin

The surrounding environments on the structure and antioxidative activity of luteolin Luteolin is an excellent antioxidant found in a wide variety of natural foods, such as honey and pollen. In this work, the effect of the surrounding environments on the structure and antioxidative activity of luteolin was carried out using density functional theory (DFT) calculation. The studied environments are gas, benzene, chloroform, pyridine, acetonitrile, ethanol, DMSO, and water. The structure of the luteolin monomer in different environments was optimized. The hydrogen-bond was especially focused, and the antioxidative capacity of luteolin was analyzed from the thermodynamic aspect. It is found that: (1) hydrogen atom transfer (HAT) is the most thermodynamically favorable mechanism in the gas, benzene, and chloroform phases, while sequential proton loss electron transfer (SPLET) is more favorable than HAT and single electron transfer followed by proton transfer (SET-PT) in pyridine, acetonitrile, ethanol, DMSO, and water phases. (2) The 4’−OH group could more strongly participate in the free radical scavenging process of luteolin than other OH groups, while the 5−OH group is the least favored one in the studied environments. (3) The antioxidative capacity of luteolin is strongest in pyridine. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Molecular Modeling Springer Journals

The surrounding environments on the structure and antioxidative activity of luteolin

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Chemistry; Computer Applications in Chemistry; Molecular Medicine; Computer Appl. in Life Sciences; Characterization and Evaluation of Materials; Theoretical and Computational Chemistry
ISSN
1610-2940
eISSN
0948-5023
D.O.I.
10.1007/s00894-018-3680-1
Publisher site
See Article on Publisher Site

Abstract

Luteolin is an excellent antioxidant found in a wide variety of natural foods, such as honey and pollen. In this work, the effect of the surrounding environments on the structure and antioxidative activity of luteolin was carried out using density functional theory (DFT) calculation. The studied environments are gas, benzene, chloroform, pyridine, acetonitrile, ethanol, DMSO, and water. The structure of the luteolin monomer in different environments was optimized. The hydrogen-bond was especially focused, and the antioxidative capacity of luteolin was analyzed from the thermodynamic aspect. It is found that: (1) hydrogen atom transfer (HAT) is the most thermodynamically favorable mechanism in the gas, benzene, and chloroform phases, while sequential proton loss electron transfer (SPLET) is more favorable than HAT and single electron transfer followed by proton transfer (SET-PT) in pyridine, acetonitrile, ethanol, DMSO, and water phases. (2) The 4’−OH group could more strongly participate in the free radical scavenging process of luteolin than other OH groups, while the 5−OH group is the least favored one in the studied environments. (3) The antioxidative capacity of luteolin is strongest in pyridine.

Journal

Journal of Molecular ModelingSpringer Journals

Published: Jun 5, 2018

References

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