The roles of vif and ORF-A genes and AP-1 binding site in in vivo replication of feline immunodeficiency virus

The roles of vif and ORF-A genes and AP-1 binding site in in vivo replication of feline... To examine the in vivo roles of auxiliary genes and regulatory elements of feline immunodeficiency virus (FIV), the provirus load in various tissues of cats infected with each of the mutant viruses (Δ vif , ΔORF-A and ΔAP-1) was studied. Although all mutant viruses could infect various tissues, provirus loads in various tissues especially those in cats infected with Δ vif virus were lower than those with the wild-type virus. Our results indicate the significance of vif and ORF-A genes and AP-1 binding site of FIV for efficient viral replication and full pathogenicity in cats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

The roles of vif and ORF-A genes and AP-1 binding site in in vivo replication of feline immunodeficiency virus

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Publisher
Springer-Verlag
Copyright
Copyright © Wien by 1998 Springer-Verlag/
Subject
Legacy
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s007050050330
Publisher site
See Article on Publisher Site

Abstract

To examine the in vivo roles of auxiliary genes and regulatory elements of feline immunodeficiency virus (FIV), the provirus load in various tissues of cats infected with each of the mutant viruses (Δ vif , ΔORF-A and ΔAP-1) was studied. Although all mutant viruses could infect various tissues, provirus loads in various tissues especially those in cats infected with Δ vif virus were lower than those with the wild-type virus. Our results indicate the significance of vif and ORF-A genes and AP-1 binding site of FIV for efficient viral replication and full pathogenicity in cats.

Journal

Archives of VirologySpringer Journals

Published: Apr 1, 1998

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