Access the full text.
Sign up today, get DeepDyve free for 14 days.
Yufang Tang, Jisen Tang, Zhangguo Chen, C. Trost, V. Flockerzi, Min Li, V. Ramesh, M. Zhu (2000)
Association of Mammalian Trp4 and Phospholipase C Isozymes with a PDZ Domain-containing Protein, NHERF*The Journal of Biological Chemistry, 275
R. Hardie, B. Minke (1992)
The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptorsNeuron, 8
C. Montell (2003)
Mg2+ Homeostasis: The Mg2+nificent TRPM ChanzymesCurrent Biology, 13
M. Aarts, K. Iihara, Wenlin Wei, Z. Xiong, M. Arundine, Waldy Cerwinski, J. Macdonald, M. Tymianski (2003)
A Key Role for TRPM7 Channels in Anoxic Neuronal DeathCell, 115
Inka Heiner, J. Eisfeld, A. Lückhoff (2003)
Role and regulation of TRP channels in neutrophil granulocytes.Cell calcium, 33 5-6
A. Perraud, C. Takanishi, B. Shen, Shin‐Sung Kang, Megan Smith, C. Schmitz, H. Knowles, D. Ferraris, Weixing Li, Jie Zhang, B. Stoddard, A. Scharenberg (2005)
Accumulation of Free ADP-ribose from Mitochondria Mediates Oxidative Stress-induced Gating of TRPM2 Cation Channels*Journal of Biological Chemistry, 280
Elena Fonfria, Ian Marshall, I. Boyfield, Stephen Skaper, Jane Hughes, D. Owen, W. Zhang, B. Miller, Christopher Benham, Shaun McNulty (2005)
Amyloid β‐peptide(1–42) and hydrogen peroxide‐induced toxicity are mediated by TRPM2 in rat primary striatal culturesJournal of Neurochemistry, 95
C. Schmitz, A. Perraud (2005)
The TRPM cation channels in the immune context.Current pharmaceutical design, 11 21
T. Chakraborti, Sudip Das, Malay Mondal, S. Roychoudhury, S. Chakraborti (1999)
Oxidant, mitochondria and calcium: an overview.Cellular signalling, 11 2
L. Davidovic, M. Vodenicharov, E. Affar, G. Poirier (2001)
Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism.Experimental cell research, 268 1
M. Bauer, M. Vogt, M. Los, J. Siegel, S. Wesselborg, K. Schulze-Osthoff (1998)
Role of Reactive Oxygen Intermediates in Activation-induced CD95 (APO-1/Fas) Ligand Expression*The Journal of Biological Chemistry, 273
Monu Goel, W. Sinkins, W. Schilling (2002)
Selective Association of TRPC Channel Subunits in Rat Brain Synaptosomes* 210The Journal of Biological Chemistry, 277
L. Tsavaler, M. Shapero, S. Morkowski, R. Laus (2001)
Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.Cancer research, 61 9
M. Crompton (1999)
The mitochondrial permeability transition pore and its role in cell death.The Biochemical journal, 341 ( Pt 2)
K. Groschner, Christian Rosker, M. Lukas (2004)
Role of TRP channels in oxidative stress.Novartis Foundation symposium, 258
Y. Hara, M. Wakamori, M. Ishii, E. Maeno, M. Nishida, Takashi Yoshida, Hisanobu Yamada, S. Shimizu, E. Mori, J. Kudoh, N. Shimizu, H. Kurose, Y. Okada, K. Imoto, Y. Mori (2002)
LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death.Molecular cell, 9 1
D. Butterfield (2003)
Amyloid beta-peptide [1-42]-associated free radical-induced oxidative stress and neurodegeneration in Alzheimer's disease brain: mechanisms and consequences.Current medicinal chemistry, 10 24
Vassilios Bezzerides, Vassilios Bezzerides, I. Ramsey, S. Kotecha, A. Greka, A. Greka, D. Clapham (2004)
Rapid vesicular translocation and insertion of TRP channelsNature Cell Biology, 6
C. Montell, G. Rubin (1989)
Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransductionNeuron, 2
Tatsuya Matsura, M. Kai, Yasuyoshi Fujii, Hisao Ito, Kazuo Yamada (1999)
Hydrogen peroxide-induced apoptosis in HL-60 cells requires caspase-3 activation.Free radical research, 30 1
L. Runnels, Lixia Yue, D. Clapham (2001)
TRP-PLIK, a Bifunctional Protein with Kinase and Ion Channel ActivitiesScience, 291
Y. Sano, Kohei Inamura, A. Miyake, S. Mochizuki, H. Yokoi, H. Matsushime, K. Furuichi (2001)
Immunocyte Ca2+ Influx System Mediated by LTRPC2Science, 293
J. Yoon, H.C. Ben-Ami, Y.S. Hong, S. Park, L.L. Strong, J. Bowman, C. Geng, K. Baek, B. Minke, W.L. Pak (2000)
Novel mechanism of massive photoreceptor degeneration caused by mutations in the trp gene ofDrosophila. J. Neurosci, 20
S. Mcnulty, E. Fonfria (2005)
The role of TRPM channels in cell deathPflügers Archiv, 451
F. Kühn, A. Lückhoff (2004)
Sites of the NUDT9-H Domain Critical for ADP-ribose Activation of the Cation Channel TRPM2*Journal of Biological Chemistry, 279
Inka Heiner, J. Eisfeld, Christian Halaszovich, E. Wehage, E. Jüngling, C. Zitt, A. Lückhoff (2003)
Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD.The Biochemical journal, 371 Pt 3
Keren Agam, M. Campenhausen, S. Levy, H. Ben-Ami, Boaz Cook, K. Kirschfeld, B. Minke (2000)
Metabolic Stress Reversibly Activates the DrosophilaLight-Sensitive Channels TRP and TRPL In VivoThe Journal of Neuroscience, 20
T. Hanano, Y. Hara, Juan Shi, H. Morita, C. Umebayashi, E. Mori, H. Sumimoto, Y. Ito, Y. Mori, R. Inoue (2004)
Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells.Journal of pharmacological sciences, 95 4
D. Rossum, R. Patterson, Sumit Sharma, R. Barrow, M. Kornberg, D. Gill, S. Snyder (2005)
Phospholipase Cγ1 controls surface expression of TRPC3 through an intermolecular PH domainNature, 434
L. Schild, G. Keilhoff, W. Augustin, G. Reiser, F. Striggow (2001)
Distinct Ca2+ thresholds determine cytochrome c release or permeability transition pore opening in brain mitochondriaThe FASEB Journal, 15
Christian Rosker, Annarita Graziani, M. Lukas, P. Eder, M. Zhu, C. Romanin, K. Groschner (2004)
Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger.The Journal of biological chemistry, 279 14
Jaeseung Yoon, H. Ben-Ami, Y. Hong, Soyeon Park, L. Strong, John Bowman, C. Geng, K. Baek, B. Minke, W. Pak (2000)
Novel Mechanism of Massive Photoreceptor Degeneration Caused by Mutations in the trp Gene of DrosophilaThe Journal of Neuroscience, 20
V. Petronilli, D. Penzo, L. Scorrano, P. Bernardi, F. Di Lisa (2001)
The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situJ. Biol. Chem, 276
D. Prawitt, T. Enklaar, G. Klemm, Barbara Gärtner, C. Spangenberg, A. Winterpacht, M. Higgins, J. Pelletier, B. Zabel (2000)
Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression.Human molecular genetics, 9 2
Hong‐Sheng Li, C. Montell (2000)
TRP and the PDZ Protein, Inad, Form the Core Complex Required for Retention of the Signalplex in Drosophila Photoreceptor CellsThe Journal of Cell Biology, 150
M. Sattler, Shalini Verma, Gautam Shrikhande, Christopher Byrne, Yuri Pride, T. Winkler, E. Greenfield, R. Salgia, J. Griffin (2000)
The BCR/ABL Tyrosine Kinase Induces Production of Reactive Oxygen Species in Hematopoietic Cells*The Journal of Biological Chemistry, 275
A. Perraud, H. Knowles, C. Schmitz (2004)
Novel aspects of signaling and ion-homeostasis regulation in immunocytes. The TRPM ion channels and their potential role in modulating the immune response.Molecular immunology, 41 6-7
T. Lockwich, Xibao Liu, Brij Singh, J. Jadlowiec, S. Weiland, I. Ambudkar (2000)
Assembly of Trp1 in a Signaling Complex Associated with Caveolin-Scaffolding Lipid Raft Domains*The Journal of Biological Chemistry, 275
E. Fonfria, Ian Marshall, C. Benham, I. Boyfield, Jason Brown, K. Hill, J. Hughes, S. Skaper, S. Mcnulty (2004)
TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP‐ribose) polymeraseBritish Journal of Pharmacology, 143
D. Clapham (2003)
TRP channels as cellular sensorsNature, 426
J. Chandra, Afshin Samali, S. Orrenius (2000)
Triggering and modulation of apoptosis by oxidative stress.Free radical biology & medicine, 29 3-4
B. Lintschinger, M. Balzer‐Geldsetzer, T. Baskaran, W. Graier, C. Romanin, M. Zhu, K. Groschner (2000)
Coassembly of Trp1 and Trp3 proteins generates diacylglycerol- and Ca2+-sensitive cation channels.The Journal of biological chemistry, 275 36
J. Kozak, M. Cahalan (2003)
MIC channels are inhibited by internal divalent cations but not ATP.Biophysical journal, 84 2 Pt 1
Qin Tong, X. Chu, J. Cheung, K. Conrad, R. Stahl, D. Barber, G. Mignery, B. Miller (2004)
Erythropoietin-modulated calcium influx through TRPC2 is mediated by phospholipase Cgamma and IP3R.American journal of physiology. Cell physiology, 287 6
P. Herson, Kevin Lee, R. Pinnock, J. Hughes, M. Ashford (1999)
Hydrogen Peroxide Induces Intracellular Calcium Overload by Activation of a Non-selective Cation Channel in an Insulin-secreting Cell Line*The Journal of Biological Chemistry, 274
R. Walder, D. Landau, P. Meyer, H. Shalev, M. Tsolia, Z. Borochowitz, M. Boettger, G. Beck, Richard Englehardt, R. Carmi, V. Sheffield (2002)
Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemiaNature Genetics, 31
James Voltz, E. Weinman, S. Shenolikar (2001)
Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulationOncogene, 20
G. Vazquez, B. Wedel, M. Trebak, Gary Bird, J. Putney (2003)
Expression Level of the Canonical Transient Receptor Potential 3 (TRPC3) Channel Determines Its Mechanism of Activation*Journal of Biological Chemistry, 278
C. Cabaner, C. Gajate, A. Macho, E. Muñoz, M. Modolell, F. Mollinedo (1999)
Induction of apoptosis in human mitogen‐activated peripheral blood T‐lymphocytes by the ether phospholipid ET‐18‐OCH3: Involvement of the Fas receptor/ligand systemBritish Journal of Pharmacology, 127
P. Klöhn, M. Soriano, William Irwin, D. Penzo, L. Scorrano, A. Bitsch, H. Neumann, P. Bernardi (2003)
Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluoreneProceedings of the National Academy of Sciences of the United States of America, 100
M. Matsushita, J. Kozak, Yoshio Shimizuʈ, D. McLachlin, H. Yamaguchi, Fan-Yan Wei, K. Tomizawa, H. Matsui, B. Chait, M. Cahalan, Angus Nairnʈ, ʈʈ (2005)
Channel Function Is Dissociated from the Intrinsic Kinase Activity and Autophosphorylation of TRPM7/ChaK1*Journal of Biological Chemistry, 280
Guylain Boulay, Darren Brown, Ning Qin, Meisheng Jiang, Alexander Dietrich, Michael Zhu, Zhangguo Chen, M. Birnbaumer, Katsuhiko Mikoshiba, Lutz Birnbaumer (1999)
Modulation of Ca 2 1 entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP): Evidence for roles of TRP and IP3R in store depletion-activated Ca 2 1 entry
A. Perraud, C. Schmitz, A. Scharenberg (2003)
TRPM2 Ca2+ permeable cation channels: from gene to biological function.Cell calcium, 33 5-6
Maria Buniel, W. Schilling, D. Kunze (2003)
Distribution of transient receptor potential channels in the rat carotid chemosensory pathwayJournal of Comparative Neurology, 464
T. Hofmann, A. Obukhov, M. Schaefer, C. Harteneck, T. Gudermann, G. Schultz (1999)
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerolNature, 397
L. Scorrano, D. Penzo, V. Petronilli, Francesco Pagano, P. Bernardi (2000)
Arachidonic Acid Causes Cell Death through the Mitochondrial Permeability TransitionThe Journal of Biological Chemistry, 276
E. Wehage, J. Eisfeld, I. Heiner, E. Jungling, C. Zitt, A. Luckhoff (2002)
Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-riboseJ. Biol. Chem, 277
Wenyi Zhang, Iwona Hirschler-Laszkiewicz, Qin Tong, K. Conrad, Shao-Cong Sun, L. Penn, D. Barber, R. Stahl, D. Carey, J. Cheung, B. Miller (2006)
TRPM2 is an ion channel that modulates hematopoietic cell death through activation of caspases and PARP cleavage.American journal of physiology. Cell physiology, 290 4
Shibin Ma, H. Ochi, L. Cui, Jianmin Zhang, Wei He (2003)
Hydrogen peroxide induced down-regulation of CD28 expression of Jurkat cells is associated with a change of site α-specific nuclear factor binding activity and the activation of caspase-3Experimental Gerontology, 38
Brett Langley, R. Ratan (2004)
Oxidative stress‐induced death in the nervous system: Cell cycle dependent or independent?Journal of Neuroscience Research, 77
Wenyi Zhang, X. Chu, Qin Tong, J. Cheung, K. Conrad, K. Masker, B. Miller (2003)
A Novel TRPM2 Isoform Inhibits Calcium Influx and Susceptibility to Cell Death*The Journal of Biological Chemistry, 278
B. Minke, Boaz Cook (2002)
TRP channel proteins and signal transduction.Physiological reviews, 82 2
C. Harteneck, T. Plant, G. Schultz (2000)
From worm to man: three subfamilies of TRP channelsTrends in Neurosciences, 23
M. Nadler, Meredith Hermosura, K. Inabe, A. Perraud, Qiqin Zhu, Alexander Stokes, T. Kurosaki, J. Kinet, R. Penner, A. Scharenberg, A. Fleig (2001)
erratum: LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viabilityNature, 412
W. Han, A. Sapirstein, C. Hung, A. Alessandrini, J. Bonventre (2003)
Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachidonic acid release.The Journal of biological chemistry, 278 26
A. Halestrap, Gavin McStay, S. Clarke (2002)
The permeability transition pore complex: another view.Biochimie, 84 2-3
C. Montell (2001)
Physiology, Phylogeny, and Functions of the TRP Superfamily of Cation ChannelsScience's STKE, 2001
S. Orrenius, B. Zhivotovsky, P. Nicotera (2003)
Regulation of cell death: the calcium-apoptosis linkNat. Rev. Mol. Cell. Biol, 4
K. Schlingmann, S. Weber, M. Peters, L. Nejsum, H. Vitzthum, K. Klingel, M. Kratz, E. Haddad, E. Ristoff, D. Dinour, M. Syrrou, S. Nielsen, M. Sassen, S. Waldegger, H. Seyberth, M. Konrad (2002)
Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene familyNature Genetics, 31
S. Orrenius, B. Zhivotovsky, P. Nicotera (2003)
Calcium: Regulation of cell death: the calcium–apoptosis linkNature Reviews Molecular Cell Biology, 4
C. Schmitz, A. Perraud, C. Johnson, K. Inabe, Megan Smith, R. Penner, T. Kurosaki, A. Fleig, A. Scharenberg (2003)
Regulation of Vertebrate Cellular Mg2+ Homeostasis by TRPM7Cell, 114
K. Nagamine, J. Kudoh, S. Minoshima, K. Kawasaki, S. Asakawa, F. Ito, N. Shimizu (1998)
Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain.Genomics, 54 1
H. Stridh, M. Kimland, Dean Jones, S. Orrenius, M. Hampton (1998)
Cytochrome c release and caspase activation in hydrogen peroxide‐ and tributyltin‐induced apoptosisFEBS Letters, 429
L. Scorrano, D. Penzo, V. Petronilli, F. Pagano, P. Bernardi (2001)
Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signalingJ. Biol. Chem, 276
D. Jo, Joon-Il Jun, Jae-Woong Chang, Yeon-mi Hong, Sungmin Song, D. Cho, S. Shim, Ho-June Lee, C. Cho, D. Kim, Yong-Keun Jung (2004)
Calcium Binding of ARC Mediates Regulation of Caspase 8 and Cell DeathMolecular and Cellular Biology, 24
T. Denning, H. Takaishi, S. Crowe, I. Boldogh, A. Jevnikar, P. Ernst (2002)
Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells.Free radical biology & medicine, 33 12
V. Petronilli, D. Penzo, L. Scorrano, P. Bernardi, F. Lisa (2001)
The Mitochondrial Permeability Transition, Release of Cytochrome c and Cell DeathThe Journal of Biological Chemistry, 276
Ying He, Guoying Yao, C. Savoia, R. Touyz (2005)
Transient Receptor Potential Melastatin 7 Ion Channels Regulate Magnesium Homeostasis in Vascular Smooth Muscle Cells: Role of Angiotensin IICirculation Research, 96
G. Vazquez, B. Wedel, B. Kawasaki, G. Bird, J. Putney (2004)
Obligatory Role of Src Kinase in the Signaling Mechanism for TRPC3 Cation Channels*Journal of Biological Chemistry, 279
E. Wehage, J. Eisfeld, Inka Heiner, E. Jüngling, C. Zitt, A. Lückhoff (2002)
Activation of the Cation Channel Long Transient Receptor Potential Channel 2 (LTRPC2) by Hydrogen PeroxideThe Journal of Biological Chemistry, 277
Monika Balzer, B. Lintschinger, K. Groschner (1999)
Evidence for a role of Trp proteins in the oxidative stress-induced membrane conductances of porcine aortic endothelial cells.Cardiovascular research, 42 2
T. Hofmann, M. Schaefer, G. Schultz, T. Gudermann (2002)
Subunit composition of mammalian transient receptor potential channels in living cellsProceedings of the National Academy of Sciences of the United States of America, 99
D. McHugh, R. Flemming, Shang‐Zhong Xu, A. Perraud, D. Beech (2003)
Critical Intracellular Ca2+ Dependence of Transient Receptor Potential Melastatin 2 (TRPM2) Cation Channel Activation*The Journal of Biological Chemistry, 278
L. Duncan, J. Deeds, J. Hunter, Jing Shao, L. Holmgren, E. Woolf, Robert Tepper, A. Shyjan (1998)
Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis.Cancer research, 58 7
Martin Kolisek, A. Beck, A. Fleig, R. Penner (2005)
Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels.Molecular cell, 18 1
G. Ermak, K. Davies (2002)
Calcium and oxidative stress: from cell signaling to cell death.Molecular immunology, 38 10
C. Leslie (1997)
Properties and Regulation of Cytosolic Phospholipase A2 *The Journal of Biological Chemistry, 272
A. Perraud, A. Fleig, Christopher Dunn, Leigh Bagley, P. Launay, C. Schmitz, Alexander Stokes, Qiqin Zhu, M. Bessman, R. Penner, J. Kinet, A. Scharenberg (2001)
ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homologyNature, 411
Jisen Tang, Yakang Lin, Zongming Zhang, S. Tikunova, L. Birnbaumer, M. Zhu (2001)
Identification of Common Binding Sites for Calmodulin and Inositol 1,4,5-Trisphosphate Receptors on the Carboxyl Termini of Trp Channels*The Journal of Biological Chemistry, 276
R. Gopalakrishna, S. Jaken (2000)
Protein kinase C signaling and oxidative stress.Free radical biology & medicine, 28 9
Santiago Partida-Sanchez, D. Cockayne, S. Monard, E. Jacobson, N. Oppenheimer, B. Garvy, Kim Kusser, S. Goodrich, M. Howard, A. Harmsen, T. Randall, F. Lund (2001)
Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivoNature Medicine, 7
R. Kraft, C. Grimm, K. Grosse, Anja Hoffmann, S. Sauerbruch, H. Kettenmann, G. Schultz, C. Harteneck (2004)
Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia.American journal of physiology. Cell physiology, 286 1
C. Strübing, G. Krapivinsky, L. Krapivinsky, D. Clapham (2001)
TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian BrainNeuron, 29
K. Venkatachalam, Hong-Tao Ma, Diana Ford, D. Gill (2001)
Expression of Functional Receptor-coupled TRPC3 Channels in DT40 Triple Receptor InsP3 knockout Cells*The Journal of Biological Chemistry, 276
P. Lipton (1999)
Ischemic cell death in brain neurons.Physiological reviews, 79 4
D. Green, G. Kroemer (2004)
The Pathophysiology of Mitochondrial Cell DeathScience, 305
W. Han, A. Sapirstein, C. Hung, A. Alessandrini, J. Bonventre (2003)
Cross-talk between Cytosolic Phospholipase A2α (cPLA2α) and Secretory Phospholipase A2 (sPLA2) in Hydrogen Peroxide-induced Arachidonic Acid Release in Murine Mesangial CellsJournal of Biological Chemistry, 278
B. Jones, C. Lo, H. Liu, Z. Pradhan, L. Garcia, A. Srinivasan, K. Valentino, M. Czaja (2000)
Role of caspases and NF-kappaB signaling in hydrogen peroxide- and superoxide-induced hepatocyte apoptosis.American journal of physiology. Gastrointestinal and liver physiology, 278 5
C. Montell (2005)
The TRP Superfamily of Cation ChannelsScience's STKE, 2005
The transient receptor potential (TRP) protein superfamily is a diverse group of voltage-independent calcium-permeable cation channels expressed in mammalian cells. These channels have been divided into six subfamilies, and two of them, TRPC and TRPM, have members that are widely expressed and activated by oxidative stress. TRPC3 and TRPC4 are activated by oxidants, which induce Na+ and Ca2+ entry into cells through mechanisms that are dependent on phospholipase C. TRPM2 is activated by oxidative stress or TNFα, and the mechanism involves production of ADP-ribose, which binds to an ADP-ribose binding cleft in the TRPM2 C-terminus. Treatment of HEK 293T cells expressing TRPM2 with H2O2 resulted in Ca2+ influx and increased susceptibility to cell death, whereas coexpression of the dominant negative isoform TRPM2-S suppressed H2O2-induced Ca2+ influx, the increase in [Ca2+]i, and onset of apoptosis. U937-ecoR monocytic cells expressing increased levels of TRPM2 also exhibited significantly increased [Ca2+]i and increased apoptosis after treatment with H2O2 or TNFα. A dramatic increase in caspase 8, 9, 3, 7, and PARP cleavage was observed in TRPM2-expressing cells, demonstrating a downstream mechanism through which cell death is mediated. Inhibition of endogenous TRPM2 function through three approaches, depletion of TRPM2 by RNA interference, blockade of the increase in [Ca2+]i through TRPM2 by calcium chelation, or expression of the dominant negative splice variant TRPM2-S protected cell viability. H2O2 and amyloid β-peptide also induced cell death in primary cultures of rat striatal cells, which endogenously express TRPM2. TRPM7 is activated by reactive oxygen species/nitrogen species, resulting in cation conductance and anoxic neuronal cell death, which is rescued by suppression of TRPM7 expression. TRPM2 and TRPM7 channels are physiologically important in oxidative stress-induced cell death.
The Journal of Membrane Biology – Springer Journals
Published: Apr 17, 2006
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.