This work provides evidence that the product of the RDH54 gene participates in the coordination of some repair pathways of DNA lesions. The unique point mutation rdh54–29 described in our previous works confers the phenotype markedly differing from that of the strain with a full deletion of gene RDH54. The epistatic type of interaction between mutations rdh 54–29 and apn 1Δ allowed the product of gene RDH54 to be attributed to the base excision repair pathway. However, a pleiotropic effect of mutation rdh54–29 manifested as sensitivity to a wide spectrum of DNA-damagi ng agents suggests that Rdh54 is involved in the regulation of several DNA repair pathways. To verify this hypothesis, the direct influence of mutation rdh54–29 on recombination and mutagenesis was evaluated. The results obtained led to the assumption that, in addition to the involvement in base excision repair, Rdh54p may play a certain role in the coordination of DNA lesion repair by various systems, including recombinational and mutagenic repair pathways or nucleotide excision repair. This function supposedly is mediated through modification of chromatin structure at the location of DNA lesion, in particular, by alleviation of DNA-hi stone bonds, thus rendering DNA more susceptible to the action of various repair proteins.
Russian Journal of Genetics – Springer Journals
Published: Mar 2, 2010
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