The Role of the Genitourinary Microbiome in Pediatric Urology: a Review

The Role of the Genitourinary Microbiome in Pediatric Urology: a Review Purpose of Review In this review, we highlight the effects of the microbiome on urologic diseases that affect the pediatric patient. Recent Findings Perturbations in the urinary microbiome have been shown to be associated with a number of urologic diseases affecting children, namely urinary tract infection, overactive bladder/urge urinary incontinence, and urolithiasis. Summary Recently, improved cultivation and sequencing technologies have allowed for the discovery of a significant and diverse microbiome in the bladder, previously assumed to be sterile. Early studies aimed to identify the resident bacterial species and demonstrate the efficacy of sequencing and enhanced quantitative urine culture. More recently, research has sought to elucidate the association between the microbiome and urologic disease, as well as to demonstrate effects of manipulation of the microbiome on various urologic pathologies. With an improved appreciation for the impact of the urinary microbiome on urologic disease, researchers have begun to explore the impact of these resident bacteria in pediatric urology. . . . . Keywords Pediatric urology Genitourinary microbiome Urologic diseases Urinary incontinence Urolithiasis Introduction aspiration or bladder biopsy) [1–3]. While the bladder has fewer commensal bacteria than sites such as the skin and co- From the 1950s, with the establishment of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Urology Reports Springer Journals

The Role of the Genitourinary Microbiome in Pediatric Urology: a Review

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Publisher
Springer US
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Medicine & Public Health; Urology; Nephrology
ISSN
1527-2737
eISSN
1534-6285
D.O.I.
10.1007/s11934-018-0763-6
Publisher site
See Article on Publisher Site

Abstract

Purpose of Review In this review, we highlight the effects of the microbiome on urologic diseases that affect the pediatric patient. Recent Findings Perturbations in the urinary microbiome have been shown to be associated with a number of urologic diseases affecting children, namely urinary tract infection, overactive bladder/urge urinary incontinence, and urolithiasis. Summary Recently, improved cultivation and sequencing technologies have allowed for the discovery of a significant and diverse microbiome in the bladder, previously assumed to be sterile. Early studies aimed to identify the resident bacterial species and demonstrate the efficacy of sequencing and enhanced quantitative urine culture. More recently, research has sought to elucidate the association between the microbiome and urologic disease, as well as to demonstrate effects of manipulation of the microbiome on various urologic pathologies. With an improved appreciation for the impact of the urinary microbiome on urologic disease, researchers have begun to explore the impact of these resident bacteria in pediatric urology. . . . . Keywords Pediatric urology Genitourinary microbiome Urologic diseases Urinary incontinence Urolithiasis Introduction aspiration or bladder biopsy) [1–3]. While the bladder has fewer commensal bacteria than sites such as the skin and co- From the 1950s, with the establishment of the

Journal

Current Urology ReportsSpringer Journals

Published: Feb 22, 2018

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