Purpose The mitogen-activated protein kinase phosphatases the insulin-induced improvement in functional recovery, but (MKPs) are a family of dual-specificity phosphatases that in- reduced infarct size. Although the data suggest a role for this activate MAPKs by dephosphorylation. Impairment of MKP- phosphatase in insulin-induced cardioprotection, the multiple 1 expression in insulin resistance has been suggested to affect downstream effects of insulin hamper interpretation of the data the cardioprotective properties of insulin. We hypothesized obtained. In addition, the effects of sanguinarine per se in myo- that manipulation of its activity during myocardial cardial ischaemia/reperfusion need to be further elucidated. ischaemia/reperfusion of control as well as insulin-resistant . . rats may affect the outcome. Keywords Cardioprotection Ischaemia/ reperfusion injury . . Methods Hearts from 16 week dietary induced obese Wistar Isolated heart perfusions MKP-1 Sanguinarine rats and their age matched controls were isolated, perfused in the working mode and subjected to 15 min global ischaemia / 30 min reperfusion or 35 min coronary artery ligation/ 60 min Introduction reperfusion. Hearts received insulin (1mIU/ml), a MKP-1 in- hibitor (sanguinarine 2.5uM), or insulin + sanguinarine for Although restitution of coronary flow to the ischaemic myo- 15 min pre- and 10 min post-ischaemia. Endpoints were
Cardiovascular Drugs and Therapy – Springer Journals
Published: May 27, 2017
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