The Role of MKP-1 in Insulin-Induced Cardioprotection

The Role of MKP-1 in Insulin-Induced Cardioprotection Purpose The mitogen-activated protein kinase phosphatases the insulin-induced improvement in functional recovery, but (MKPs) are a family of dual-specificity phosphatases that in- reduced infarct size. Although the data suggest a role for this activate MAPKs by dephosphorylation. Impairment of MKP- phosphatase in insulin-induced cardioprotection, the multiple 1 expression in insulin resistance has been suggested to affect downstream effects of insulin hamper interpretation of the data the cardioprotective properties of insulin. We hypothesized obtained. In addition, the effects of sanguinarine per se in myo- that manipulation of its activity during myocardial cardial ischaemia/reperfusion need to be further elucidated. ischaemia/reperfusion of control as well as insulin-resistant . . rats may affect the outcome. Keywords Cardioprotection Ischaemia/ reperfusion injury . . Methods Hearts from 16 week dietary induced obese Wistar Isolated heart perfusions MKP-1 Sanguinarine rats and their age matched controls were isolated, perfused in the working mode and subjected to 15 min global ischaemia / 30 min reperfusion or 35 min coronary artery ligation/ 60 min Introduction reperfusion. Hearts received insulin (1mIU/ml), a MKP-1 in- hibitor (sanguinarine 2.5uM), or insulin + sanguinarine for Although restitution of coronary flow to the ischaemic myo- 15 min pre- and 10 min post-ischaemia. Endpoints were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cardiovascular Drugs and Therapy Springer Journals

The Role of MKP-1 in Insulin-Induced Cardioprotection

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer Science+Business Media New York
Subject
Medicine & Public Health; Cardiology
ISSN
0920-3206
eISSN
1573-7241
D.O.I.
10.1007/s10557-017-6731-4
Publisher site
See Article on Publisher Site

Abstract

Purpose The mitogen-activated protein kinase phosphatases the insulin-induced improvement in functional recovery, but (MKPs) are a family of dual-specificity phosphatases that in- reduced infarct size. Although the data suggest a role for this activate MAPKs by dephosphorylation. Impairment of MKP- phosphatase in insulin-induced cardioprotection, the multiple 1 expression in insulin resistance has been suggested to affect downstream effects of insulin hamper interpretation of the data the cardioprotective properties of insulin. We hypothesized obtained. In addition, the effects of sanguinarine per se in myo- that manipulation of its activity during myocardial cardial ischaemia/reperfusion need to be further elucidated. ischaemia/reperfusion of control as well as insulin-resistant . . rats may affect the outcome. Keywords Cardioprotection Ischaemia/ reperfusion injury . . Methods Hearts from 16 week dietary induced obese Wistar Isolated heart perfusions MKP-1 Sanguinarine rats and their age matched controls were isolated, perfused in the working mode and subjected to 15 min global ischaemia / 30 min reperfusion or 35 min coronary artery ligation/ 60 min Introduction reperfusion. Hearts received insulin (1mIU/ml), a MKP-1 in- hibitor (sanguinarine 2.5uM), or insulin + sanguinarine for Although restitution of coronary flow to the ischaemic myo- 15 min pre- and 10 min post-ischaemia. Endpoints were

Journal

Cardiovascular Drugs and TherapySpringer Journals

Published: May 27, 2017

References

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