The role of microRNAs in hepatitis C virus RNA replication

The role of microRNAs in hepatitis C virus RNA replication Replication of hepatitis C virus (HCV) RNA is influenced by a variety of microRNAs, with the main player being the liver-specific microRNA-122 (miR-122). Binding of miR-122 to two binding sites near the 5′ end of the 5′ untranslated region (UTR) of the HCV genomic RNA results in at least two different effects. On the one hand, binding of miR-122 and the resulting recruitment of protein complexes containing Argonaute (Ago) proteins appears to mask the viral RNA′s 5′ end and stabilizes the viral RNA against nucleolytic degradation. On the other hand, this interaction of miR-122 with the 5′-UTR also stimulates HCV RNA translation directed by the internal ribosome entry site (IRES) located downstream of the miR-122 binding sites. However, it is suspected that additional, yet undefined roles of miR-122 in HCV replication may also contribute to HCV propagation. Accordingly, miR-122 is considered to contribute to the liver tropism of the virus. Besides miR-122, let-7b, miR-196, miR-199a* and miR-448 have also been reported to interact directly with the HCV RNA. However, the latter microRNAs inhibit HCV replication, and it has been speculated that miR-199a* contributes indirectly to HCV tissue tropism, since it is mostly expressed in cells other than hepatocytes. Other microRNAs influence HCV replication indirectly. Some of those are advantageous for HCV propagation, while others suppress HCV replication. Consequently, HCV up-regulates or down-regulates, respectively, the expression of most of these miRNAs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

The role of microRNAs in hepatitis C virus RNA replication

Loading next page...
 
/lp/springer_journal/the-role-of-micrornas-in-hepatitis-c-virus-rna-replication-lwKTVI50A4
Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-013-1883-4
Publisher site
See Article on Publisher Site

Abstract

Replication of hepatitis C virus (HCV) RNA is influenced by a variety of microRNAs, with the main player being the liver-specific microRNA-122 (miR-122). Binding of miR-122 to two binding sites near the 5′ end of the 5′ untranslated region (UTR) of the HCV genomic RNA results in at least two different effects. On the one hand, binding of miR-122 and the resulting recruitment of protein complexes containing Argonaute (Ago) proteins appears to mask the viral RNA′s 5′ end and stabilizes the viral RNA against nucleolytic degradation. On the other hand, this interaction of miR-122 with the 5′-UTR also stimulates HCV RNA translation directed by the internal ribosome entry site (IRES) located downstream of the miR-122 binding sites. However, it is suspected that additional, yet undefined roles of miR-122 in HCV replication may also contribute to HCV propagation. Accordingly, miR-122 is considered to contribute to the liver tropism of the virus. Besides miR-122, let-7b, miR-196, miR-199a* and miR-448 have also been reported to interact directly with the HCV RNA. However, the latter microRNAs inhibit HCV replication, and it has been speculated that miR-199a* contributes indirectly to HCV tissue tropism, since it is mostly expressed in cells other than hepatocytes. Other microRNAs influence HCV replication indirectly. Some of those are advantageous for HCV propagation, while others suppress HCV replication. Consequently, HCV up-regulates or down-regulates, respectively, the expression of most of these miRNAs.

Journal

Archives of VirologySpringer Journals

Published: May 1, 2014

References

  • Hepatitis C virus proteins: from structure to function
    Moradpour, D; Penin, F
  • Hepatitis C viral protein translation: mechanisms and implications in developing antivirals
    Hoffman, B; Liu, Q
  • Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
    Wang, Y; Juranek, S; Li, H; Sheng, G; Tuschl, T; Patel, DJ
  • A three-dimensional view of the molecular machinery of RNA interference
    Jinek, M; Doudna, JA
  • Identification of tissue-specific microRNAs from mouse
    Lagos-Quintana, M; Rauhut, R; Yalcin, A; Meyer, J; Lendeckel, W; Tuschl, T
  • Stimulation of Hepatitis C Virus RNA translation by microRNA-122 occurs under different conditions in vivo and in vitro
    Goergen, D; Niepmann, M
  • Decreased levels of microRNA miR-122 in individuals with hepatitis C responding poorly to interferon therapy
    Sarasin-Filipowicz, M; Krol, J; Markiewicz, I; Heim, MH; Filipowicz, W
  • Let-7b is a novel regulator of hepatitis C virus replication
    Cheng, JC; Yeh, YJ; Tseng, CP; Hsu, SD; Chang, YL; Sakamoto, N; Huang, HD
  • MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins
    Hou, W; Tian, Q; Zheng, J; Bonkovsky, HL
  • Alterations in microRNA expression profile in HCV-infected hepatoma cells: involvement of miR-491 in regulation of HCV replication via the PI3 kinase/Akt pathway
    Ishida, H; Tatsumi, T; Hosui, A; Nawa, T; Kodama, T; Shimizu, S; Hikita, H; Hiramatsu, N; Kanto, T; Hayashi, N; Takehara, T
  • Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma
    Ura, S; Honda, M; Yamashita, T; Ueda, T; Takatori, H; Nishino, R; Sunakozaka, H; Sakai, Y; Horimoto, K; Kaneko, S
  • Parallel microRNA and mRNA expression profiling of (genotype 1b) human hepatoma cells expressing hepatitis C virus
    Steuerwald, NM; Parsons, JC; Bennett, K; Bates, TC; Bonkovsky, HL

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off