The role of Gilgamesh protein kinase in Drosophila melanogaster spermatogenesis

The role of Gilgamesh protein kinase in Drosophila melanogaster spermatogenesis The cellular function of the gilgamesh mutation (89B9-12) of casein kinase gene in Drosophila spermatogenesis was studied. It was demonstrated that the sterility resulting from this mutation is connected with the abnormalities in spermatid individualization. A phylogenetic study of the protein sequences of casein kinases 1 from various organisms was conducted. The Gilgamesh protein was shown to be phylogenetically closer to the cytoplasmic casein kinase family, represented by the YCK3, YCK2, and YCK1 proteins of Saccharomyces cerevisiae and animal γ-casein kinases. It is known that these yeast casein kinases are involved in vesicular trafficking, which, in turn, is related in its genetic control to the cell membrane remodeling during spermatid individualization. Thus, the data of phylogenetic analysis fit well the results obtained by studying the mutation phenotype. Russian Journal of Genetics Springer Journals

The role of Gilgamesh protein kinase in Drosophila melanogaster spermatogenesis

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SP MAIK Nauka/Interperiodica
Copyright © 2008 by MAIK Nauka
Biomedicine; Microbial Genetics and Genomics; Animal Genetics and Genomics; Human Genetics
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