J. Membrane Biol. 162, 1–7 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Topical Review The Role of Anionic Lipids in Protein Insertion and Translocation in Bacterial Membranes W. van Klompenburg*, B. de Kruijff Department of Biochemistry of Membranes, Centre for Biomembranes and Lipid Enzymology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands Received: 28 July 1997 Introduction separated by the so-called periplasmic space. Transloca- tion and insertion are well studied in this organism and because of the advanced genetics, the phospholipid com- Insertion of proteins into and translocation across bio- position of the inner membrane can be manipulated very logical membranes are essential for cellular processes efficiently by controlling the key enzymes in the lipid such as membrane biogenesis and secretion. Both inser- biosynthetic pathways. In this way the role of lipids in tion and translocation involve membrane passage of hy- translocation and insertion can be studied in living cells. drophilic polypeptide segments and transfer of hydro- phobic segments from the aqueous environment of the cytosol to the hydrophobic core of the membrane. Over Phospholipids in the Inner Membrane of E. coli the last decade these processes have been extensively
The Journal of Membrane Biology – Springer Journals
Published: Mar 1, 1998
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