The role of 18F-FDG PET/CT in the detection of osteosarcoma recurrence

The role of 18F-FDG PET/CT in the detection of osteosarcoma recurrence Eur J Nucl Med Mol Imaging (2017) 44:1712–1720 DOI 10.1007/s00259-017-3698-0 ORIGINAL ARTICLE The role of F-FDG PET/CT in the detection of osteosarcoma recurrence 1 2 2 2 Andrea Angelini & Francesco Ceci & Paolo Castellucci & Tiziano Graziani & 2 1 3 3 Giulia Polverari & Giulia Trovarelli & Emanuela Palmerini & Stefano Ferrari & 2 1 Stefano Fanti & Pietro Ruggieri Received: 12 January 2017 /Accepted: 28 March 2017 /Published online: 12 April 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract in 2.7% (1/37) case; multiple sites of uptake in 32.4% (12/37). Aim The aim of this study was to investigate the diagnostic Histology resulted positive in 92% (34/37) of patients. A total accuracy of F-FDG-PET/CT in osteosarcoma patients sus- of 51 pathologic lesions were evaluated (22 local relapse, 11 picious for disease recurrence after adequate surgical therapy. lung metastasis, 10 metastatic LNs, eight distant metastatic Methods Inclusion criteria were: a) adequate surgical treatment lesions). On a per-patient analysis F-FDG-PET/CT showed for proven osteosarcoma and documented complete remission a sensitivity, specificity, accuracy, PPV, and NPV of 91%, after therapy; b) F-FDG-PET/CT performed during follow- 75%, 89%, 97%, 50%. On a per-site analysis the performance up for clinical/diagnostic suspicion of relapse; European Journal of Nuclear Medicine and Molecular Imaging Springer Journals

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Medicine & Public Health; Nuclear Medicine; Imaging / Radiology; Orthopedics; Cardiology; Oncology
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