The right timing for post-ischemic stunning

The right timing for post-ischemic stunning EDITORIAL a a Dominik C. Benz, MD, and Oliver Gaemperli, MD, FESC Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland Received Mar 8, 2016; accepted Mar 8, 2016 doi:10.1007/s12350-016-0473-8 The first unequivocal direct evidence for myocar- See related article, pp. 1292–1301 dial stunning in humans was published by Gerber and colleagues in 1999. They investigated 14 patients with unstable angina who were successfully revascularized, Myocardial stunning refers to a state of prolonged but showed persistent wall motion abnormalities contractile dysfunction of post-ischemic myocardium in 48 hours after revascularization despite restoration of which normal myocardial function is gradually restored myocardial blood flow (MBF). Four months later, 86% after a given recovery period. The first description of of patients displayed spontaneous improvement in seg- this phenomenon dates back to the early 30’s, where mental wall motion. In patients with stable angina, Tennant and Wiggers demonstrated in their seminal Barnes and colleagues observed that dobutamine stress experiments in open-chest dogs that, within 60 seconds induced similar reductions of myocardial contractility in of coronary occlusion, myocardial contractions in the ischemic myocardium, which recovered slowly over the ischemic zone change from active systolic shortening to course of several hours. Interestingly, if Journal of Nuclear Cardiology Springer Journals

The right timing for post-ischemic stunning

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Springer US
Copyright © 2016 by American Society of Nuclear Cardiology
Medicine & Public Health; Cardiology; Nuclear Medicine; Imaging / Radiology
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