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D. Joller (2009)
Comparative molecular approaches to identify host determinants mediating adhesion of E. coli F4 strains in pigs
M. Jacobsen, S. Kracht, G. Esteso, S. Cirera, I. Edfors, A. Archibald, C. Bendixen, L. Andersson, M. Fredholm, C. Jørgensen (2010)
Refined candidate region specified by haplotype sharing for Escherichia coli F4ab/F4ac susceptibility alleles in pigs.Animal genetics, 41 1
K. Karlsson (1998)
Meaning and therapeutic potential of microbial recognition of host glycoconjugatesMolecular Microbiology, 29
B. Zhang, J. Ren, X. Yan, X. Huang, H. Ji, Q. Peng, Z. Zhang, L. Huang (2008)
Investigation of the porcine MUC13 gene: isolation, expression, polymorphisms and strong association with susceptibility to enterotoxigenic Escherichia coli F4ab/ac.Animal genetics, 39 3
A. Ramos, R. Crooijmans, N. Affara, A. Amaral, A. Archibald, J. Beever, C. Bendixen, C. Churcher, R. Clark, Patrick Dehais, M. Hansen, J. Hedegaard, Zhi-Liang Hu, H. Kerstens, A. Law, H. Megens, D. Milan, D. Nonneman, G. Rohrer, M. Rothschild, Tim Smith, R. Schnabel, C. Tassell, Jeremy Taylor, R. Wiedmann, L. Schook, M. Groenen (2009)
Design of a High Density SNP Genotyping Assay in the Pig Using SNPs Identified and Characterized by Next Generation Sequencing TechnologyPLoS ONE, 4
D. Joller, C. Jørgensen, H. Bertschinger, E. Bürgi, C. Stannarius, P. Mortensen, S. Cirera, A. Archibald, S. Genini, I. Edfors-Lilja, L. Andersson, M. Fredholm, Peter Vögli (2006)
Refined linkage mapping of the Escherichia coli F4ac receptor gene on pig chromosome 13
P. Vögeli, R. Bolt, R. Fries, G. Stranzinger (1994)
Co-segregation of the malignant hyperthermia and the Arg615-Cys615 mutation in the skeletal muscle calcium release channel protein in five European Landrace and Pietrain pig breeds.Animal genetics, 25 Suppl 1
C. Jørgensen, S. Cirera, S. Anderson, A. Archibald, T. Raudsepp, B. Chowdhary, I. Edfors-Lilja, Leif Andersson, M. Fredholm (2004)
Linkage and comparative mapping of the locus controlling susceptibility towards E. coli F4ab/ac diarrhoea in pigsCytogenetic and Genome Research, 102
I., G. Bijlsma, A., De, Nijs, C., van der, Meer, J. Frik (1982)
Different pig phenotypes affect adherence of Escherichia coli to jejunal brush borders by K88ab, K88ac, or K88ad antigenInfection and Immunity, 37
J. Wang, Si-wen Jiang, X. Chen, Zhihong Liu, J. Peng (2006)
Prevalence of Fimbrial Antigen (K88 variants, K99 and 987P) of Enterotoxigenic Escherichia Coli from Neonatal and Post-weaning Piglets with Diarrhea in Central ChinaAsian-australasian Journal of Animal Sciences, 19
E. Meijerink, S. Neuenschwander, R. Fries, A. Dinter, H. Bertschinger, G. Stranzinger, P. Vögeli (2000)
A DNA polymorphism influencing α(1,2)fucosyltransferase activity of the pig FUT1 enzyme determines susceptibility of small intestinal epithelium to Escherichia coli F18 adhesionImmunogenetics, 52
G. Abecasis, S. Cherny, W. Cookson, L. Cardon (2002)
Merlin—rapid analysis of dense genetic maps using sparse gene flow treesNature Genetics, 30
P. Vögeli, H. Bertschinger, M. Stamm, C. Stricker, C. Hagger, R. Fries, J. Rapacz, G. Stranzinger (1996)
Genes specifying receptors for F18 fimbriated Escherichia coli, causing oedema disease and postweaning diarrhoea in pigs, map to chromosome 6.Animal genetics, 27 5
R. Gibbons, R. Sellwood, M. Burrows, P. Hunter (1977)
Inheritance of resistance to neonatal E. coli diarrhoea in the pig: examination of the genetic systemTheoretical and Applied Genetics, 51
Myron Levine (2010)
Escherichia coli InfectionsThe New England Journal of Medicine, 313
P. Python, H. Jörg, S. Neuenschwander, C. Hagger, C. Stricker, E. Bürgi, H. Bertschinger, G. Stranzinger, P. Vögeli (2002)
Fine-mapping of the intestinal receptor locus for enterotoxigenic Escherichia coli F4ac on porcine chromosome 13.Animal genetics, 33 6
E. Meijerink, R. Fries, P. Vögeli, J. Masabanda, G. Wigger, C. Stricker, S. Neuenschwander, H. Bertschinger, G. Stranzinger (1997)
Two α(1,2) fucosyltransferase genes on porcine Chromosome 6q11 are closely linked to the blood group inhibitor (S) and Escherichia coli F18 receptor (ECF18R) lociMammalian Genome, 8
I. Edfors-Lilja, U. Gustafsson, Y. Duval-Iflah, H. Ellergren, M. Johansson, R. Juneja, L. Marklund, L. Andersson (1995)
The porcine intestinal receptor for Escherichia coli K88ab, K88ac: regional localization on chromosome 13 and influence of IgG response to the K88 antigen.Animal genetics, 26 4
D. Joller, C. Jørgensen, H. Bertschinger, P. Python, I. Edfors, S. Cirera, A. Archibald, E. Bürgi, P. Karlskov-Mortensen, L. Andersson, M. Fredholm, P. Vögeli (2009)
Refined localization of the Escherichia coli F4ab/F4ac receptor locus on pig chromosome 13.Animal genetics, 40 5
A. Erickson, D. Baker, B. Bosworth, T. Casey, D. Benfield, David Francis (1994)
Characterization of porcine intestinal receptors for the K88ac fimbrial adhesin of Escherichia coli as mucin-type sialoglycoproteinsInfection and Immunity, 62
J. Zimmerman (2012)
Diseases of swine
H. Thiele, P. Nürnberg (2005)
HaploPainter: a tool for drawing pedigrees with complex haplotypesBioinformatics, 21 8
P. Rippinger, H. Bertschinger, H. Imberechts, B. Nagy, I. Sorg, M. Stamm, P. Wild, W. Wittig (1995)
Designations F18ab and F18ac for the related fimbrial types F107, 2134P and 8813 of Escherichia coli isolated from porcine postweaning diarrhoea and from oedema disease.Veterinary microbiology, 45 4
K. Rasschaert, F. Verdonck, B. Goddeeris, L. Duchateau, E. Cox (2007)
Screening of pigs resistant to F4 enterotoxigenic Escherichia coli (ETEC) infection.Veterinary microbiology, 123 1-3
J. Osek (1999)
Prevalence of virulence factors of Escherichia coli strains isolated from diarrheic and healthy piglets after weaning.Veterinary microbiology, 68 3-4
Enterotoxigenic Escherichia coli (ETEC) with fimbriae of the F4 family are one of the major causes of diarrhea and death among neonatal and young piglets. Bacteria use the F4 fimbriae to adhere to specific receptors expressed on the surface of the enterocytes. F4 fimbriae exist in three different antigenic variants, F4ab, F4ac, and F4ad, of which F4ac is the most common. Resistance to ETEC F4ab/F4ac adhesion in pigs has been shown to be inherited as an autosomal recessive trait. In previous studies the ETEC F4ab/F4ac receptor locus (F4bcR) was mapped to the q41 region on pig chromosome 13. A polymorphism within an intron of the mucin 4 (MUC4) gene, which is one of the possible candidate genes located in this region, was shown earlier to cosegregate with the F4bcR alleles. Recently, we discovered a Large White boar from a Swiss experimental herd with a recombination between F4bcR and MUC4. A three–generation pedigree including 45 offspring was generated with the aim to use this recombination event to refine the localization of the F4bcR locus. All pigs were phenotyped using the microscopic adhesion test and genotyped for a total of 59 markers. The recombination event was mapped to a 220-kb region between a newly detected SNP in the leishmanolysin-like gene (LMLN g.15920) and SNP ALGA0072075. In this study the six SNPs ALGA0072075, ALGA0106330, MUC13-226, MUC13-813, DIA0000584, and MARC0006918 were in complete linkage disequilibrium with F4bcR. Based on this finding and earlier investigations, we suggest that the locus for F4bcR is located between the LMLN locus and microsatellite S0283.
Mammalian Genome – Springer Journals
Published: Dec 7, 2010
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