The prqA and mvrA Genes Encoding Drug Efflux Proteins Control Resistance to Methyl Viologen in the Cyanobacterium Synechocystis sp. PCC 6803

The prqA and mvrA Genes Encoding Drug Efflux Proteins Control Resistance to Methyl Viologen in... Derivatives with insertional inactivation of prqA and mvrAgenes were obtained and studied in the Synechocystis sp. PCC 6803 wild-type strain and in the mutant Prq20 resistant to methyl viologen (MV). It was shown that the formation of resistance to MV is associated with the operation of two systems: constitutive and inducible. TheprqAgene encoding drug efflux protein controls the constitutive system of cell resistance to MV. Derepression of the prqA gene is the main reason for an enhanced MV resistance in the Prq20 mutant with impaired repressor function of the PrqR protein. The mvrA gene encoding the transmembrane protein from the family of transporters of sugar and other compounds controls the inducible MV resistance. It is assumed that the MvrA protein is required for efficient elimination from cells of toxic substances formed upon oxidative stress or participates in the repair of membranes destroyed by oxidants. The data obtained demonstrated for the first time that transport systems are involved in the development of MV resistance in photosynthetic organisms. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Russian Journal of Genetics Springer Journals

The prqA and mvrA Genes Encoding Drug Efflux Proteins Control Resistance to Methyl Viologen in the Cyanobacterium Synechocystis sp. PCC 6803

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Publisher
Kluwer Academic Publishers-Plenum Publishers
Copyright
Copyright © 2003 by MAIK “Nauka/Interperiodica”
Subject
Biomedicine; Human Genetics
ISSN
1022-7954
eISSN
1608-3369
D.O.I.
10.1023/A:1023256608389
Publisher site
See Article on Publisher Site

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