J Anesth (2017) 31:163–169 DOI 10.1007/s00540-016-2284-0 ORIGINAL ARTICLE The protective effect of human atrial natriuretic peptide on renal damage during cardiac surgery 1 1 1 2 Takahiro Moriyama · Shintaro Hagihara · Toko Shiramomo · Misaki Nagaoka · 1 1 Shohei Iwakawa · Yuichi Kanmura Received: 20 July 2016 / Accepted: 6 November 2016 / Published online: 16 November 2016 © The Author(s) 2016. This article is published with open access at Springerlink.com Abstract protein (L-FABP) were measured during and after surgery Purpose Acute kidney injury (AKI) is one of the critical in both groups. Plasma renin activity, Ang II, aldosterone complications after cardiac surgery. In the kidney, angio- and serum creatinine were also measured. tensin II (Ang II) is formed by independent mechanisms, Results Urinary angiotensinogen levels in the hANP group and activity of the intrarenal renin–angiotensin–aldosterone were significantly lower than in the non-hANP group after (RAAS) system contributes to the progression of kidney cardiopulmonary bypass surgery, at the end of surgery and damage. Although atrial natriuretic peptide (ANP) exerts 3 h after surgery. At 3 h after surgery, urinary NGAL lev- protective effects against renal injury by inhibiting the els in the hANP and non-hANP groups were
Journal of Anesthesia – Springer Journals
Published: Nov 16, 2016
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