The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro

The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast... Breast Cancer (2017) 24:658–666 DOI 10.1007/s12282-017-0752-5 ORIGINAL ARTICLE The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro 1 1 1 • • Satoshi Tanaka Kanayo Suzuki Minoru Sakaguchi Received: 3 October 2016 / Accepted: 3 January 2017 / Published online: 9 January 2017 The Japanese Breast Cancer Society 2017 Abstract (CDK4), E2F1, and retinoblastoma protein (pRb) expres- Background Prolyl oligopeptidase (POP, EC 3.4.1.26) is a sion; and increased cyclin-dependent kinase inhibitor 1B kip1 serine peptidase that hydrolyzes post-proline peptide bonds (p27 ) expression. Moreover, the SUAM-14746-medi- in peptides that are \30 amino acids in length. We previ- ated cell cycle arrest of MCF7 cells was associated with ously reported that POP inhibition suppressed the growth increased pRb2/p130 protein expression and an increase in of NB-1 human neuroblastomas cells and KATO III human the number of cells in the quiescent G state, as defined by gastric cancer cells. POP activity is commonly elevated in low RNA levels. many cancers, which includes breast cancer. However, the Conclusions SUAM-14746 inhibited breast cancer cell effect of POP inhibition as a candidate breast cancer growth in a cytostatic manner without inducing lethality, therapy is unknown. and POP-specific http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Breast Cancer Springer Journals

The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro

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Publisher
Springer Japan
Copyright
Copyright © 2017 by The Japanese Breast Cancer Society
Subject
Medicine & Public Health; Surgical Oncology; Oncology; Surgery; Cancer Research
ISSN
1340-6868
eISSN
1880-4233
D.O.I.
10.1007/s12282-017-0752-5
Publisher site
See Article on Publisher Site

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