The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro

The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast... Breast Cancer (2017) 24:658–666 DOI 10.1007/s12282-017-0752-5 ORIGINAL ARTICLE The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro 1 1 1 • • Satoshi Tanaka Kanayo Suzuki Minoru Sakaguchi Received: 3 October 2016 / Accepted: 3 January 2017 / Published online: 9 January 2017 The Japanese Breast Cancer Society 2017 Abstract (CDK4), E2F1, and retinoblastoma protein (pRb) expres- Background Prolyl oligopeptidase (POP, EC 3.4.1.26) is a sion; and increased cyclin-dependent kinase inhibitor 1B kip1 serine peptidase that hydrolyzes post-proline peptide bonds (p27 ) expression. Moreover, the SUAM-14746-medi- in peptides that are \30 amino acids in length. We previ- ated cell cycle arrest of MCF7 cells was associated with ously reported that POP inhibition suppressed the growth increased pRb2/p130 protein expression and an increase in of NB-1 human neuroblastomas cells and KATO III human the number of cells in the quiescent G state, as defined by gastric cancer cells. POP activity is commonly elevated in low RNA levels. many cancers, which includes breast cancer. However, the Conclusions SUAM-14746 inhibited breast cancer cell effect of POP inhibition as a candidate breast cancer growth in a cytostatic manner without inducing lethality, therapy is unknown. and POP-specific http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Breast Cancer Springer Journals

The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro

Loading next page...
 
/lp/springer_journal/the-prolyl-oligopeptidase-inhibitor-suam-14746-attenuates-the-YNXh7TNXSF
Publisher
Springer Japan
Copyright
Copyright © 2017 by The Japanese Breast Cancer Society
Subject
Medicine & Public Health; Surgical Oncology; Oncology; Surgery; Cancer Research
ISSN
1340-6868
eISSN
1880-4233
D.O.I.
10.1007/s12282-017-0752-5
Publisher site
See Article on Publisher Site

Abstract

Breast Cancer (2017) 24:658–666 DOI 10.1007/s12282-017-0752-5 ORIGINAL ARTICLE The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro 1 1 1 • • Satoshi Tanaka Kanayo Suzuki Minoru Sakaguchi Received: 3 October 2016 / Accepted: 3 January 2017 / Published online: 9 January 2017 The Japanese Breast Cancer Society 2017 Abstract (CDK4), E2F1, and retinoblastoma protein (pRb) expres- Background Prolyl oligopeptidase (POP, EC 3.4.1.26) is a sion; and increased cyclin-dependent kinase inhibitor 1B kip1 serine peptidase that hydrolyzes post-proline peptide bonds (p27 ) expression. Moreover, the SUAM-14746-medi- in peptides that are \30 amino acids in length. We previ- ated cell cycle arrest of MCF7 cells was associated with ously reported that POP inhibition suppressed the growth increased pRb2/p130 protein expression and an increase in of NB-1 human neuroblastomas cells and KATO III human the number of cells in the quiescent G state, as defined by gastric cancer cells. POP activity is commonly elevated in low RNA levels. many cancers, which includes breast cancer. However, the Conclusions SUAM-14746 inhibited breast cancer cell effect of POP inhibition as a candidate breast cancer growth in a cytostatic manner without inducing lethality, therapy is unknown. and POP-specific

Journal

Breast CancerSpringer Journals

Published: Jan 9, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off