Breast Cancer Res Treat (2017) 165:391–402 DOI 10.1007/s10549-017-4333-2 EPIDEMIOLOGY The prognostic effect of estrogen receptor status differs for younger versus older breast cancer patients 1 1 1 • • Victoria Sopik Ping Sun Steven A. Narod Received: 17 April 2017 / Accepted: 7 June 2017 / Published online: 10 June 2017 Springer Science+Business Media, LLC 2017 Abstract diagnosed before age 40, breast cancer-speciﬁc survival at Purpose To estimate the prognostic impact of estrogen 15 years was worse for those with ER-positive breast receptor (ER)-status among women with primary invasive cancer than for those with ER-negative breast cancer (55 breast cancer, according to age at diagnosis. vs. 61%; adjusted HR = 0.90; 95% CI 0.57–1.41; Methods We studied 1910 women with primary invasive p = 0.64). In contrast, among 1697 women diagnosed breast cancer (stages I–III) who were treated at Women’s between ages 40 and 75, breast cancer-speciﬁc survival at College Hospital between 1987 and 2000. For each patient, 15 years was better for those with ER-positive breast we obtained information on age at diagnosis, tumour size, cancer than for those with ER-negative breast cancer (78 lymph node status, ER-status, treatments received (radio- vs. 72%; adjusted HR = 0.60; 95%
Breast Cancer Research and Treatment – Springer Journals
Published: Jun 10, 2017
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