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F. Farinati, A. Vitale, G. Spolverato, T. Pawlik, T. Huo, Yun‐Hsuan Lee, A. Frigo, A. Giacomin, E. Giannini, F. Ciccarese, F. Piscaglia, G. Rapaccini, M. Marco, E. Caturelli, M. Zoli, F. Borzio, G. Cabibbo, M. Felder, R. Sacco, F. Morisco, E. Biasini, F. Foschi, A. Gasbarrini, G. Baroni, R. Virdone, A. Masotto, F. Trevisani, U. Cillo (2016)
Development and Validation of a New Prognostic System for Patients with Hepatocellular CarcinomaPLoS Medicine, 13
PH Liu, CY Hsu, YH Lee (2015)
Hong Kong liver cancer staging system is associated with better performance for hepatocellular carcinoma: special emphasis on viral etiologyMedicine (Baltimore), 94
X. Adhoute, G. Pénaranda, J. Raoul, J. Blanc, J. Edeline, Guillaume Conroy, H. Perrier, B. Pol, O. Bayle, O. Monnet, P. Beaurain, C. Muller, P. Castellani, J. Bronowicki, M. Bourliere (2015)
Prognosis of advanced hepatocellular carcinoma: a new stratification of Barcelona Clinic Liver Cancer stage C results from a French multicenter studyEuropean Journal of Gastroenterology & Hepatology, 28
M. Kudo, Hobyung Chung, S. Haji, Y. Osaki, H. Oka, T. Seki, H. Kasugai, Y. Sasaki, T. Matsunaga (2004)
Validation of a new prognostic staging system for hepatocellular carcinoma: The JIS score compared with the CLIP scoreHepatology, 40
J. Llovet, C. Brú, J. Bruix (1999)
Prognosis of Hepatocellular Carcinoma: The BCLC Staging ClassificationSeminars in Liver Disease, 19
M. Wallace, Yi Huang, D. Preen, G. Garas, L. Adams, G. Macquillan, J. Tibballs, J. Ferguson, S. Samuelson, G. Jeffrey (2017)
HKLC Triages More Hepatocellular Carcinoma Patients to Curative Therapies Compared to BCLC and Is Associated with Better SurvivalDigestive Diseases and Sciences, 62
Lily Wu, A. Bartlett, L. Plank, J. McCall (2016)
Validation of the Hong Kong liver cancer staging system in hepatocellular carcinoma patients treated with curative intent.Journal of hepatology, 64 4
P. Johnson, S. Berhane, Chiaki Kagebayashi, S. Satomura, M. Teng, H. Reeves, J. O’Beirne, R. Fox, A. Skowrońska, D. Palmer, W. Yeo, F. Mo, P. Lai, M. Iñarrairaegui, S. Chan, B. Sangro, R. Miksad, T. Tada, T. Kumada, H. Toyoda (2015)
Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33 6
R. Romagnoli, Vincenzo Mazzaferro, Jordi Bruix (2016)
ReplyHepatology, 63
P. Galle, A. Forner, J. Llovet, V. Mazzaferro, F. Piscaglia, J. Raoul, P. Schirmacher, V. Vilgrain (2018)
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma.Journal of hepatology, 69 1
J. Sohn, R. Duran, Yan Zhao, F. Fleckenstein, J. Chapiro, Sonia Sahu, R. Schernthaner, T. Qian, Howard Lee, Li Zhao, J. Hamilton, C. Frangakis, Mingde Lin, R. Salem, J. Geschwind (2017)
Validation of the Hong Kong Liver Cancer Staging System in Determining Prognosis of the North American Patients Following Intra‐arterial TherapyClinical Gastroenterology & Hepatology, 15
Xiaopeng Yan, Xu Fu, Chuang Cai, Xuejian Zi, H. Yao, Y. Qiu (2015)
Validation of models in patients with hepatocellular carcinoma: comparison of Hong Kong Liver Cancer with Barcelona Clinic Liver Cancer staging system in a Chinese cohortEuropean Journal of Gastroenterology & Hepatology, 27
X. Adhoute, G. Pénaranda, J. Bronowicki, J. Raoul (2015)
Usefulness of the HKLC vs. the BCLC staging system in a European HCC cohort.Journal of hepatology, 62 2
LH Sobin, CC Compton (2010)
TNM seventh edition: what’s new, what’s changed: communication from the International Union Against Cancer and the American Joint Committee on CancerCancer, 116
Po‐Hong Liu, Chia-Yang Hsu, Yun‐Hsuan Lee, C. Su, C. Hsia, Yi‐Hsiang Huang, Y. Chiou, Han‐Chieh Lin, T. Huo (2015)
Hong Kong Liver Cancer Staging System Is Associated With Better Performance for Hepatocellular CarcinomaMedicine, 94
R. Siegel, Jiemin Ma, Zhaohui Zou, A. Jemal (2014)
Cancer statistics, 2014CA: A Cancer Journal for Clinicians, 64
J. Petrick, M. Braunlin, M. Laversanne, P. Valery, F. Bray, K. McGlynn (2016)
International trends in liver cancer incidence, overall and by histologic subtype, 1978–2007International Journal of Cancer, 139
Kwang-Min Kim, D. Sinn, Sin-Ho Jung, G. Gwak, Y. Paik, M. Choi, J. Lee, K. Koh, S. Paik (2016)
The recommended treatment algorithms of the BCLC and HKLC staging systems: does following these always improve survival rates for HCC patients?Liver International, 36
J. Bruix, M. Sherman (2011)
Management of hepatocellular carcinoma: An updateHepatology (Baltimore, Md.), 53
P. Kolly, H. Reeves, B. Sangro, M. Knöpfli, D. Candinas, J. Dufour (2016)
Assessment of the Hong Kong Liver Cancer Staging System in EuropeLiver International, 36
T. Yau, Vikki Tang, T. Yao, S. Fan, C. Lo, R. Poon (2014)
Development of Hong Kong Liver Cancer staging system with treatment stratification for patients with hepatocellular carcinoma.Gastroenterology, 146 7
(2012)
EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma.Journal of hepatology, 56 4
Kunio Okuda, Toshio Ohtsuki, H. Obata, M. Tomimatsu, N. Okazaki, H. Hasegawa, Y. Nakajima, K. Ohnishi (1985)
Natural history of hepatocellular carcinoma and prognosis in relation to treatment study of 850 patientsCancer, 56
R. Angelis, M. Sant, M. Coleman, S. Francisci, P. Baili, D. Pierannunzio, A. Trama, O. Visser, H. Brenner, E. Ardanaz, M. Bielska-Lasota, G. Engholm, A. Nennecke, S. Siesling, F. Berrino, R. Capocaccia (2014)
Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE--5-a population-based study.The Lancet. Oncology, 15 1
F. Greene, L. Sobin (2008)
The Staging of Cancer: A Retrospective and Prospective AppraisalCA: A Cancer Journal for Clinicians, 58
J. Yang, J. Larson, K. Watt, A. Allen, R. Wiesner, G. Gores, L. Roberts, J. Heimbach, M. Leise (2017)
Hepatocellular Carcinoma Is the Most Common Indication for Liver Transplantation and Placement on the Waitlist in the United StatesClinical Gastroenterology & Hepatology, 15
Po‐Hong Liu, Chia-Yang Hsu, C. Hsia, Yun‐Hsuan Lee, C. Su, Yi‐Hsiang Huang, F. Lee, Han‐Chieh Lin, T. Huo (2016)
Prognosis of hepatocellular carcinoma: Assessment of eleven staging systems.Journal of hepatology, 64 3
M. Wallace, D. Preen, G. Jeffrey, L. Adams (2015)
The evolving epidemiology of hepatocellular carcinoma: a global perspectiveExpert Review of Gastroenterology & Hepatology, 9
Giuseppe Manghisi, S. Elba, A. Mossa, A. Giorgio, V. Aloisio, A. Perrotta, B. Tardio, C. Naja, E. Caturelli, M. Calandra, L. Castellano, I. Sio, G. Capuano, D. Pomponi, F. Castiglione, Pasqualina Cocchia, F. Farinati, M. Rinaldi, L. Adinolfi, E. Ragone, M. Felder, L. Zancanella, G. Pasquale, M. Stanzione, G. Marone, V. D’Angelo, G. Gaeta, G. Giolitto, Bruno Lamborgese, L. Manzione, M. Russo, Raffaele Colurcio, E. Veltri, F. Izzo, G. Budillon, N. Caporaso, C. Blanco, B. Galanti, G. Giusti, G. Mazzacca, S. Monfardini, F. Piccinino, G. Ruggiero, C. Gallo, F. Perrone, S. Placido, G. Canzanella, B. Daniele, S. Pignata (1998)
A new prognostic system for hepatocellular carcinoma: A retrospective study of 435 patientsHepatology, 28
L. Sobin, C. Compton (2010)
TNM seventh edition: What's new, what's changedCancer, 116
D. White, A. Thrift, F. Kanwal, J. Davila, H. El‐Serag (2017)
Incidence of Hepatocellular Carcinoma in All 50 United States, From 2000 Through 2012.Gastroenterology, 152 4
Background and Aims There has been significant debate regarding which hepatocellular carcinoma (HCC) staging system is best able to predict survival. We hypothesized that the prognostic ability of the Barcelona Clinic Liver Cancer (BCLC) and Hong Kong Liver Cancer (HKLC) systems would be improved with the addition of an explicit treatment variable. Methods We performed an analysis of a prospectively enrolled cohort of 292 patients undergoing 532 treatment episodes for HCC from 2006 to 2014. BCLC, standard nine-stage HKLC (HKLC9), and modified five-stage HKLC (HKLC5) for each treatment episode were assessed. Overall survival and time to disease progression were calculated for the initial treat- ment, re-treatment, and overall treatment cohorts. We compared the performance of various prognostic models including staging system alone, treatment alone, and staging system plus treatment using the corrected Akaike information criterion and Harrell’s C statistic. Results The BCLC, HKLC5, and HKLC9 systems were significant predictors of survival and time to progression for all treatment cohorts (log rank test, p < 0.001). The addition of a treatment variable significantly improved ( p < 0.01) the prog- nostic ability of the survival and time to progression models compared with those containing only the BCLC or HKLC stage
Digestive Diseases and Sciences – Springer Journals
Published: May 28, 2018
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