The prevalence of human herpes viruses in the saliva of chronic periodontitis patients compared to oral health providers and healthy controls

The prevalence of human herpes viruses in the saliva of chronic periodontitis patients compared... The causative agents in periodontal disease are periopathogenic bacteria; however, viruses have been implicated. The aim of this study was to examine the prevalence of different HHVs in the saliva of chronic periodontitis patients and to compare it to two groups of healthy controls. Three groups were included: chronic periodontitis patients (CP), periodontally healthy patients (NP) and oral health providers with a healthy periodontium (NPOHP). For each subject, 1 ml of unstimulated whole saliva was collected and mixed with 2 ml lysis buffer. HHVs assays were performed using real-time PCR. Fifteen percent of the subjects in the CP group tested positive for CMV compared to none in the NP and NPOHP groups (p = 0.04). Recurrent herpes was more frequent in females (51.7 %) than in males (33.3 %), and this was statistically significant (p = 0.038). The higher prevalence of CMV in the unstimulated saliva of CP patients suggests that CMV may play a role in the pathogenesis of chronic periodontitis. Archives of Virology Springer Journals

The prevalence of human herpes viruses in the saliva of chronic periodontitis patients compared to oral health providers and healthy controls

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Springer Vienna
Copyright © 2013 by Springer-Verlag Wien
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
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  • Herpesviruses in human periodontal disease
    Contreras, A; Slots, J
  • Periodontopathic bacteria and herpesviruses in chronic periodontitis
    Chalabi, M; Rezaie, F; Moghim, S; Mogharehabed, A; Rezaei, M; Mehraban, B
  • Genomic organization and evolution of the human herpesviruses
    Weir, JP
  • Cytomegalovirus, human herpesvirus-6, and human herpesvirus-7 in hematological patients
    Clark, DA; Emery, VC; Griffiths, PD
  • Seroprevalence of antibodies to human herpesviruses in England and Hong Kong
    Kangro, HO; Osman, HK; Lau, YL; Heath, RB; Yeung, CY; Ng, MH
  • EBV and CMV in chronic periodontitis: a prevalence study
    Chalabi, M; Moghim, S; Mogharehabed, A; Najafi, F; Rezaie, F

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