Curr Allergy Asthma Rep (2017) 17:62 DOI 10.1007/s11882-017-0730-1 ASTHMA (WJ CALHOUN AND V ORTEGA, SECTION EDITORS) The Potential for Emerging Microbiome-Mediated Therapeutics in Asthma 1 2 3,4,5 Ayse Bilge Ozturk & Benjamin Arthur Turturice & David L. Perkins & 2,3 Patricia W. Finn Springer Science+Business Media, LLC 2017 Abstract asthma phenotypes and for protection against asthma during Purpose of Review In terms of immune regulating functions, early life. analysis of the microbiome has led the development of thera- Summary Current clinical evidence does not support the use peutic strategies that may be applicable to asthma manage- of these therapies for effective treatment of asthma. The inte- ment. This review summarizes the current literature on the gration of the data regarding microbiota with technologic ad- gut and lung microbiota in asthma pathogenesis with a focus vances, such as next generation sequencing and omics offers on the roles of innate molecules and new microbiome- promise. Combining comprehensive bioinformatics, new mediated therapeutics. molecules and approaches may shape future asthma treatment. Recent Findings Recent clinical and basic studies to date have . . . identified several possible therapeutics that can target innate Keywords Asthma Innate immunity Interleukin-33 . . immunity and the microbiota
Current Allergy and Asthma Reports – Springer Journals
Published: Aug 10, 2017
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