The Potential for Emerging Microbiome-Mediated Therapeutics in Asthma

The Potential for Emerging Microbiome-Mediated Therapeutics in Asthma Curr Allergy Asthma Rep (2017) 17:62 DOI 10.1007/s11882-017-0730-1 ASTHMA (WJ CALHOUN AND V ORTEGA, SECTION EDITORS) The Potential for Emerging Microbiome-Mediated Therapeutics in Asthma 1 2 3,4,5 Ayse Bilge Ozturk & Benjamin Arthur Turturice & David L. Perkins & 2,3 Patricia W. Finn Springer Science+Business Media, LLC 2017 Abstract asthma phenotypes and for protection against asthma during Purpose of Review In terms of immune regulating functions, early life. analysis of the microbiome has led the development of thera- Summary Current clinical evidence does not support the use peutic strategies that may be applicable to asthma manage- of these therapies for effective treatment of asthma. The inte- ment. This review summarizes the current literature on the gration of the data regarding microbiota with technologic ad- gut and lung microbiota in asthma pathogenesis with a focus vances, such as next generation sequencing and omics offers on the roles of innate molecules and new microbiome- promise. Combining comprehensive bioinformatics, new mediated therapeutics. molecules and approaches may shape future asthma treatment. Recent Findings Recent clinical and basic studies to date have . . . identified several possible therapeutics that can target innate Keywords Asthma Innate immunity Interleukin-33 . . immunity and the microbiota http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

The Potential for Emerging Microbiome-Mediated Therapeutics in Asthma

The Potential for Emerging Microbiome-Mediated Therapeutics in Asthma

Curr Allergy Asthma Rep (2017) 17:62 DOI 10.1007/s11882-017-0730-1 ASTHMA (WJ CALHOUN AND V ORTEGA, SECTION EDITORS) The Potential for Emerging Microbiome-Mediated Therapeutics in Asthma 1 2 3,4,5 Ayse Bilge Ozturk & Benjamin Arthur Turturice & David L. Perkins & 2,3 Patricia W. Finn Springer Science+Business Media, LLC 2017 Abstract asthma phenotypes and for protection against asthma during Purpose of Review In terms of immune regulating functions, early life. analysis of the microbiome has led the development of thera- Summary Current clinical evidence does not support the use peutic strategies that may be applicable to asthma manage- of these therapies for effective treatment of asthma. The inte- ment. This review summarizes the current literature on the gration of the data regarding microbiota with technologic ad- gut and lung microbiota in asthma pathogenesis with a focus vances, such as next generation sequencing and omics offers on the roles of innate molecules and new microbiome- promise. Combining comprehensive bioinformatics, new mediated therapeutics. molecules and approaches may shape future asthma treatment. Recent Findings Recent clinical and basic studies to date have . . . identified several possible therapeutics that can target innate Keywords Asthma Innate immunity Interleukin-33 . . immunity and the microbiota in asthma. Some of these drugs Microbiota Thymic stromal lymphopoietin Toll-like have shown beneficial effects in the treatment of certain receptors Introduction This article is part of the Topical Collection on Asthma Asthma is the most common disease in both children and * Patricia W. Finn pwfinn@uic.edu adults and it is estimated that the number individuals with asthma will grow by more than 100 million by 2025 [1]. Ayse Bilge Ozturk aozturk@kuh.ku.edu.tr Environmental changes arising from Western lifestyles and urbanization are closely associated with the increased prev- Benjamin Arthur Turturice alence of asthma, and...
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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer Science+Business Media, LLC
Subject
Medicine & Public Health; Allergology
ISSN
1529-7322
eISSN
1534-6315
D.O.I.
10.1007/s11882-017-0730-1
Publisher site
See Article on Publisher Site

Abstract

Curr Allergy Asthma Rep (2017) 17:62 DOI 10.1007/s11882-017-0730-1 ASTHMA (WJ CALHOUN AND V ORTEGA, SECTION EDITORS) The Potential for Emerging Microbiome-Mediated Therapeutics in Asthma 1 2 3,4,5 Ayse Bilge Ozturk & Benjamin Arthur Turturice & David L. Perkins & 2,3 Patricia W. Finn Springer Science+Business Media, LLC 2017 Abstract asthma phenotypes and for protection against asthma during Purpose of Review In terms of immune regulating functions, early life. analysis of the microbiome has led the development of thera- Summary Current clinical evidence does not support the use peutic strategies that may be applicable to asthma manage- of these therapies for effective treatment of asthma. The inte- ment. This review summarizes the current literature on the gration of the data regarding microbiota with technologic ad- gut and lung microbiota in asthma pathogenesis with a focus vances, such as next generation sequencing and omics offers on the roles of innate molecules and new microbiome- promise. Combining comprehensive bioinformatics, new mediated therapeutics. molecules and approaches may shape future asthma treatment. Recent Findings Recent clinical and basic studies to date have . . . identified several possible therapeutics that can target innate Keywords Asthma Innate immunity Interleukin-33 . . immunity and the microbiota

Journal

Current Allergy and Asthma ReportsSpringer Journals

Published: Aug 10, 2017

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