The phosphodiesterase-4 inhibitor roflumilast decreases ethanol consumption in C57BL/6J mice

The phosphodiesterase-4 inhibitor roflumilast decreases ethanol consumption in C57BL/6J mice Rationale Alcohol use disorders have become one of the most ethanol intake and preference in C57BL/6J mice treated with damaging psychiatric disorders in the world; however, there roflumilast (1, 3, or 10 mg/kg) or rolipram (0.5 mg/kg; posi- are no ideal treatments in clinic. Phosphodiesterase-4 (PDE4), tive control). The effect of roflumilast was verified using the an enzyme that specifically hydrolyzes intracellular cyclic ethanol drinking-in-dark (DID) test. Locomotor activity was AMP (cAMP), has been involved in alcohol use disorders. examined using the open-field test. Intake of sucrose or qui- Roflumilast is the first PDE4 inhibitor approved for treatment nine was also tested to determine whether natural reward pref- of chronic obstructive pulmonary diseases in clinic. It was of erence and aversive stimuli were involved in the effect of particular interest to researchers to determine whether PDE4 inhibitors. roflumilast altered ethanol consumption. Results Similar to rolipram, roflumilast decreased ethanol in- Objectives The present study tried to determine the effects of take and preference in two-bottle choice and DID tests in a roflumilast on ethanol intake and preference. dose-dependent manner, with significant changes at the dose of 10 mg/kg; in contrast, roflumilast did not affect sucrose or quinine drinking, although it Psychopharmacology Springer Journals

The phosphodiesterase-4 inhibitor roflumilast decreases ethanol consumption in C57BL/6J mice

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
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