The Pharmacology and Toxicology of Third-Generation Anticonvulsant Drugs

The Pharmacology and Toxicology of Third-Generation Anticonvulsant Drugs Epilepsy is a neurologic disorder affecting approximately 50 million people worldwide, or about 0.7% of the population [1]. Thus, the use of anticonvulsant drugs in the treatment of epilepsy is common and widespread. There are three generations of anticonvulsant drugs, categorized by the year in which they were developed and released. The aim of this review is to discuss the pharmacokinetics, drug-drug interactions, and adverse events of the third generation of anticonvulsant drugs. Where available, overdose data will be included. The pharmacokinetic properties of third-generation anticonvulsant drugs include relatively fewer drug-drug interactions, as well as several unique and life-threatening adverse events. Overdose data are limited, so thorough review of adverse events and knowledge of drug mechanism will guide expectant management of future overdose cases. Reporting of these cases as they occur will be necessary to further clarify toxicity of these drugs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Medical Toxicology Springer Journals

The Pharmacology and Toxicology of Third-Generation Anticonvulsant Drugs

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Publisher
Springer US
Copyright
Copyright © 2017 by American College of Medical Toxicology
Subject
Biomedicine; Pharmacology/Toxicology; Biomedicine, general
ISSN
1556-9039
eISSN
1937-6995
D.O.I.
10.1007/s13181-017-0626-4
Publisher site
See Article on Publisher Site

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