ISSN 10623604, Russian Journal of Developmental Biology, 2011, Vol. 42, No. 2, pp. 132–133. © Pleiades Publishing, Inc., 2011. Original Russian Text © M.M. Aslanyan, O.P. Soldatova, 2011, published in Ontogenez, 2011, Vol. 42, No. 2, pp. 159–160. LETTER TO THE EDITOR The Paper Titled Somatic Sex Reprogramming of Adult Ovaries to Testes by foxl2 Ablation by the Research Team Headed by Mathias Treier Was Published In December in the Cell, Vol. 139, Issue 6, pp. 1130–1142 DOI: 10.1134/S1062360411020044 The history and discovery of the key gene deter the events caused by ablation of this gene in adult mice mining development of the testes in mammals has with normally developed ovaries using sitespecific been associated with almost 20yearold search for the recombination. For this purpose, the mouse strains testisdetermining factor (TFD), which ended with with CreLoxP sites were bred; one female strain, f/f the discovery of the SRY gene, whose sexdetermining Foxl2 , carried the Foxl2 gene flanked with LoxP sites f/f function was confirmed in the experiment with the XX and the other, R26CreERT2;Foxl2 carried the transgenic mice carrying a 14kb fragment of this gene recombinase gene (Cre) fused with the estrogen recep (Sinclair et al., 1990; Koopman
Russian Journal of Developmental Biology – Springer Journals
Published: Apr 7, 2011
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