The P-Glycoprotein Efflux Pump: How Does it Transport Drugs?

The P-Glycoprotein Efflux Pump: How Does it Transport Drugs? J. Membrane Biol. 166, 71–73 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Letters to the Editor Received: 17 June 1998 Sir, more confused. When Sharom concludes mutations in A recent topical review on Pgp–mediated drug transport Pgp “. . . alter both drug resistance...and drug- by F.J. Sharom (J. Membrane Biol. 160:161–175) con- stimulated ATP hydrolysis profiles...”she neglects that tains a number of errors and omissions. A more com- these experiments typically compare cell lines selected plete analysis of all available data would be of benefit. or conditioned on different concentrations of complex Proper discussion of other models [1–4] that do not vio- drugs (or different drugs). Currently, it is unclear wheth- late fundamental laws as do drug pump models, requires er phenotypic differences are even due to mutant Pgps. attention to biophysical principles [1] that are not fully “Pumping” assays that have been used to draw many entertained by Sharom. conclusions have almost always been zero trans efflux To understand controversy in this field we must fol- (or influx) measurements, where transport against a con- low its history. Starting nearly 30 years ago multidrug centration gradient (i.e., “pumping” in the correct sense) resistant http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

The P-Glycoprotein Efflux Pump: How Does it Transport Drugs?

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Publisher
Springer-Verlag
Copyright
Copyright © 1998 by Springer-Verlag New York Inc.
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s002329900448
Publisher site
See Article on Publisher Site

Abstract

J. Membrane Biol. 166, 71–73 (1998) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1998 Letters to the Editor Received: 17 June 1998 Sir, more confused. When Sharom concludes mutations in A recent topical review on Pgp–mediated drug transport Pgp “. . . alter both drug resistance...and drug- by F.J. Sharom (J. Membrane Biol. 160:161–175) con- stimulated ATP hydrolysis profiles...”she neglects that tains a number of errors and omissions. A more com- these experiments typically compare cell lines selected plete analysis of all available data would be of benefit. or conditioned on different concentrations of complex Proper discussion of other models [1–4] that do not vio- drugs (or different drugs). Currently, it is unclear wheth- late fundamental laws as do drug pump models, requires er phenotypic differences are even due to mutant Pgps. attention to biophysical principles [1] that are not fully “Pumping” assays that have been used to draw many entertained by Sharom. conclusions have almost always been zero trans efflux To understand controversy in this field we must fol- (or influx) measurements, where transport against a con- low its history. Starting nearly 30 years ago multidrug centration gradient (i.e., “pumping” in the correct sense) resistant

Journal

The Journal of Membrane BiologySpringer Journals

Published: Feb 2, 2014

References

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