J. Membrane Biol. 160, 161–175 (1997) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1997 Topical Review F.J. Sharom Guelph-Waterloo Centre for Graduate Work in Chemistry and Biochemistry, University of Guelph, Guelph, Ontario Canada N1G 2W1 Received: 3 April 1997/Revised: 11 June 1997 Introduction drug-resistant tumors [29–32], and many Phase I and II clinical trials have been carried out, or are in progress. The development of multidrug resistance (MDR) is a Pgp is also found in several normal human tissues, in- major obstacle in the chemotherapeutic treatment of cluding the apical surface of many epithelial cells and the many human cancers, including colon, kidney and breast endothelial cells of the blood brain barrier. Its physi- carcinomas, leukemias, multiple myeloma, and pediatric ological role is not yet clear, although it appears to be cancers. Resistant tumors are found to be cross-resistant involved in protection against toxic natural products. to a broad but well-defined spectrum of structurally un- This review will focus on the molecular properties of related cytotoxic drugs, including the Vinca alkaloids, Pgp with respect to binding and transport of substrates, anthracyclines, epipodophyllotoxins, and taxanes (Table and how these properties can be related to the possible 1).
The Journal of Membrane Biology – Springer Journals
Published: Dec 1, 1997
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera