The Overlapping Thermodynamic Dissociation Constants of the Antidepressant Vortioxetine Using UV–VIS Multiwavelength pH-Titration Data

The Overlapping Thermodynamic Dissociation Constants of the Antidepressant Vortioxetine Using... Keywords Dissociation constants  Vortioxetine  Spectrophotometric titration  REACTLAB  SQUAD84  ESAB 1 Introduction Vortioxetine hydrobromide (trade name Brintellix, Trintellix in Canada) with the IUPAC name 1-(2-((2,4-dimethyl-phenyl)thio)phenyl)piperazine hydrobromide, a molecular for- -1 mula of C H N SHBr, and molecular weight of 379.36 gmol , is an atypical antide- 18 22 2 pressant (a serotonin modulator and stimulator) made by Lundbeck [1] and Takeda [2]. It relieves depression symptoms by increasing serotonin concentrations in the brain, by inhibiting its reuptake in the synapses and by modulating (activating certain receptors while blocking, or antagonizing, others) certain serotonin receptors. This puts it in the class of atypical antidepressants known as serotonin modulators and stimulators [3, 4]. On 30 September 2013 it was approved by the U.S. FDA for the treatment of major depressive disorders in adults. Vortioxetine was also examined as a treatment for generalized anxiety disorder but was not found to be superior to the placebo [5]. Depressive disorders, including major depressive disorders, are common mental health conditions thought to be caused by an imbalance in serotonin (5-HT) and norepinephrine, in addition to having multiple situational, cognitive, and medical factors [6]. The most common side effects reported with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Solution Chemistry Springer Journals

The Overlapping Thermodynamic Dissociation Constants of the Antidepressant Vortioxetine Using UV–VIS Multiwavelength pH-Titration Data

Meloun, Milan; Pilařová, Lucie; Čápová, Aneta; Pekárek, Tomáš
Journal of Solution Chemistry , Volume 47 (5) – May 17, 2018
21 pages
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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Chemistry; Physical Chemistry; Industrial Chemistry/Chemical Engineering; Geochemistry; Oceanography; Inorganic Chemistry; Condensed Matter Physics
ISSN
0095-9782
eISSN
1572-8927
D.O.I.
10.1007/s10953-018-0757-5
Publisher site
See Article on Publisher Site

Abstract

Keywords Dissociation constants  Vortioxetine  Spectrophotometric titration  REACTLAB  SQUAD84  ESAB 1 Introduction Vortioxetine hydrobromide (trade name Brintellix, Trintellix in Canada) with the IUPAC name 1-(2-((2,4-dimethyl-phenyl)thio)phenyl)piperazine hydrobromide, a molecular for- -1 mula of C H N SHBr, and molecular weight of 379.36 gmol , is an atypical antide- 18 22 2 pressant (a serotonin modulator and stimulator) made by Lundbeck [1] and Takeda [2]. It relieves depression symptoms by increasing serotonin concentrations in the brain, by inhibiting its reuptake in the synapses and by modulating (activating certain receptors while blocking, or antagonizing, others) certain serotonin receptors. This puts it in the class of atypical antidepressants known as serotonin modulators and stimulators [3, 4]. On 30 September 2013 it was approved by the U.S. FDA for the treatment of major depressive disorders in adults. Vortioxetine was also examined as a treatment for generalized anxiety disorder but was not found to be superior to the placebo [5]. Depressive disorders, including major depressive disorders, are common mental health conditions thought to be caused by an imbalance in serotonin (5-HT) and norepinephrine, in addition to having multiple situational, cognitive, and medical factors [6]. The most common side effects reported with

Journal

Journal of Solution Chemistry – Springer Journals

Published: May 17, 2018

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