The Overlapping Thermodynamic Dissociation Constants of the Antidepressant Vortioxetine Using UV–VIS Multiwavelength pH-Titration Data

The Overlapping Thermodynamic Dissociation Constants of the Antidepressant Vortioxetine Using... Keywords Dissociation constants  Vortioxetine  Spectrophotometric titration  REACTLAB  SQUAD84  ESAB 1 Introduction Vortioxetine hydrobromide (trade name Brintellix, Trintellix in Canada) with the IUPAC name 1-(2-((2,4-dimethyl-phenyl)thio)phenyl)piperazine hydrobromide, a molecular for- -1 mula of C H N SHBr, and molecular weight of 379.36 gmol , is an atypical antide- 18 22 2 pressant (a serotonin modulator and stimulator) made by Lundbeck [1] and Takeda [2]. It relieves depression symptoms by increasing serotonin concentrations in the brain, by inhibiting its reuptake in the synapses and by modulating (activating certain receptors while blocking, or antagonizing, others) certain serotonin receptors. This puts it in the class of atypical antidepressants known as serotonin modulators and stimulators [3, 4]. On 30 September 2013 it was approved by the U.S. FDA for the treatment of major depressive disorders in adults. Vortioxetine was also examined as a treatment for generalized anxiety disorder but was not found to be superior to the placebo [5]. Depressive disorders, including major depressive disorders, are common mental health conditions thought to be caused by an imbalance in serotonin (5-HT) and norepinephrine, in addition to having multiple situational, cognitive, and medical factors [6]. The most common side effects reported with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Solution Chemistry Springer Journals

The Overlapping Thermodynamic Dissociation Constants of the Antidepressant Vortioxetine Using UV–VIS Multiwavelength pH-Titration Data

Download PDF
21 pages
Read Article

Loading next page...
 
/lp/springer_journal/the-overlapping-thermodynamic-dissociation-constants-of-the-x7wB18Hz7f
Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Chemistry; Physical Chemistry; Industrial Chemistry/Chemical Engineering; Geochemistry; Oceanography; Inorganic Chemistry; Condensed Matter Physics
ISSN
0095-9782
eISSN
1572-8927
DOI
10.1007/s10953-018-0757-5
Publisher site
See Article on Publisher Site

Abstract

Keywords Dissociation constants  Vortioxetine  Spectrophotometric titration  REACTLAB  SQUAD84  ESAB 1 Introduction Vortioxetine hydrobromide (trade name Brintellix, Trintellix in Canada) with the IUPAC name 1-(2-((2,4-dimethyl-phenyl)thio)phenyl)piperazine hydrobromide, a molecular for- -1 mula of C H N SHBr, and molecular weight of 379.36 gmol , is an atypical antide- 18 22 2 pressant (a serotonin modulator and stimulator) made by Lundbeck [1] and Takeda [2]. It relieves depression symptoms by increasing serotonin concentrations in the brain, by inhibiting its reuptake in the synapses and by modulating (activating certain receptors while blocking, or antagonizing, others) certain serotonin receptors. This puts it in the class of atypical antidepressants known as serotonin modulators and stimulators [3, 4]. On 30 September 2013 it was approved by the U.S. FDA for the treatment of major depressive disorders in adults. Vortioxetine was also examined as a treatment for generalized anxiety disorder but was not found to be superior to the placebo [5]. Depressive disorders, including major depressive disorders, are common mental health conditions thought to be caused by an imbalance in serotonin (5-HT) and norepinephrine, in addition to having multiple situational, cognitive, and medical factors [6]. The most common side effects reported with

Journal

Journal of Solution Chemistry – Springer Journals

Published: May 17, 2018

References

  • Profile of vortioxetine in the treatment of major depressive disorder: an overview of the primary and secondary literature
    Kelliny, M; Croarkin, PE; Moore, KM; Bobo, WV
  • The serotonergic system in the neurobiology of depression: relevance for novel antidepressants
    Kohler, S; Cierpinsky, K; Kronenberg, G; Adli, M
  • Vortioxetine (Lu AA21004) 5 mg in generalized anxiety disorder: results of an 8-week randomized, double-blind, placebo-controlled clinical trial in the United States
    Rothschild, AJ; Mahableshwarkar, AR; Jacobsen, P; Yan, M; Sheehan, DV
  • The safety and efficacy of vortioxetine for acute treatment of major depressive disorder: a systematic review and meta-analysis
    Meeker, AS; Herink, MC; Haxby, DG; Hartung, DM
  • A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder
    Katona, C; Hansen, T; Olsen, CK
  • A review on various analytical methods used in determination of dissociation constant
    Pathare, B; Tambe, V; Patil, V
  • Development of methods for the determination of pKa values
    Reijenga, J; Hoof, AV; Loon, AV; Teunissen, B
  • New chemometric strategies in the spectrophotometric determination of pKa
    Hernández, JA; Hernández, AR; Urbina, EMC; Rodríguez, IMDLG; Manzanares, MV; Medina-Vallejo, LF
  • Application of chemometrics in determination of the acid dissociation constants (pK(a)) of several benzodiazepine derivatives as poorly soluble drugs in the presence of ionic surfactants
    Shayesteh, TH; Radmehr, M; Khajavi, F; Mahjub, R
  • Determination of pK(a) of felodipine using UV–visible spectroscopy
    Pandey, MM; Jaipal, A; Kumar, A; Malik, R; Charde, SY
  • The pK(a) distribution of drugs: application to drug discovery
    Manallack, DT
  • New and original pKa prediction method using grid molecular interaction fields
    Milletti, F; Storchi, L; Sforna, G; Cruciani, G
  • Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds
    Settimo, L; Bellman, K; Knegtel, RA
  • Multiwavelength spectrophotometric determination of acid dissociation constants: a validation study
    Tam, KY; Takacs-Novak, K
  • Multiwavelength spectrophotometric determination of acid dissociation constants of ionizable drugs
    Allen, RI; Box, KJ; Comer, JEA; Peake, C; Tam, KY
  • Solution Equilibria
    Hartley, FR; Burgess, C; Alcock, RM
  • General computer program for the computation of stability constants from absorbance data
    Leggett, DJ; McBryde, WAE
  • Computation of equilibrium constants for multicomponent systems from spectrophotometric data
    Kankare, JJ
  • Reliability of dissociation constants and resolution capability of SQUAD(84) and SPECFIT/32 in the regression of multiwavelength spectrophotometric pH-titration data
    Meloun, M; Ferenčíková, Z; Javůrek, M
  • The dissociation constants of the cytostatic bosutinib by nonlinear least-squares regression of multiwavelength spectrophotometric and potentiometric pH-titration data
    Meloun, M; Nečasová, V; Javůrek, M; Pekárek, T
  • Tutorial on a chemical model building by least-squares non-linear regression of multiwavelength spectrophotometric pH-titration data
    Meloun, M; Bordovská, S; Syrový, T; Vrána, A
  • A novel computational strategy for the pK(a) estimation of drugs by non-linear regression of multiwavelength spectrophotometric pH-titration data exhibiting small spectral changes
    Meloun, M; Bordovská, S; Syrový, T
  • Structures and physicochemical properties of vortioxetine salts
    Zhou, X; Hu, X; Wu, S; Ye, J; Sun, M; Gu, J; Zhu, J; Zhang, Z
  • Comparison of nine programs predicting pK(a) values of pharmaceutical substances
    Liao, CZ; Nicklaus, MC
  • Benchmarking and validating algorithms that estimate pK(a) values of drugs based on their molecular structures
    Meloun, M; Bordovská, S
  • Comparative evaluation of in silico pK(a) prediction tools on the gold standard dataset
    Balogh, GT; Gyarmati, B; Nagy, B; Molnar, L; Keseru, GM
  • Critical comparison of methods predicting the number of components in spectroscopic data
    Meloun, M; Čapek, J; Mikšík, P; Brereton, RG
  • Computation of Solution Equilibria: A guide to Methods in Potentiometry, Extraction, and Spectrophotometry. Ellis Horwood Series in Analytical Chemistry
    Meloun, M; Havel, J; Högfeldt, E
  • Reliability and uncertainty in the estimation of pK(a) by least squares nonlinear regression analysis of multiwavelength spectrophotometric pH titration data
    Meloun, M; Syrový, T; Bordovská, S; Vrána, A
  • The thermodynamic dissociation constants of the anticancer drugs camptothecine, 7-ethyl-10-hydroxycamptothecine, 10-hydroxycamptothecine and 7-ethylcamptothecine by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration data
    Meloun, M; Bordovská, S; Vrána, A
  • Chemometrics for Analytical Chemistry. PC-Aided Regression and Related Methods
    Meloun, M; Militký, J; Forina, M
  • Computer-analysis of equilibrium data in solution—a compact least-squares computer-program for acid–base titrations
    Rigano, C; Grasso, M; Sammartano, S
  • Computer analysis of equilibrium data in solution ESAB2 M: an improved version of the ESAB program
    Stefano, C; Princi, P; Rigano, C; Sammartano, S
  • Chemometrics for Analytical Chemistry. PC-Aided Statistical Data Analysis
    Meloun, M; Militký, J; Forina, M

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off

Sign up
for free
Start 14 day
Free Trial