The genomes of eight granuloviruses (GVs), have been analyzed for the presence of homologous regions ( hr s) that may act as origins of replication. Thirteen 74–76-bp palindromes within 11 hr s have previously been identified in the Cydia pomonella GV (CpGV) genome and found to replicate in an infection-dependent DNA replication assay. We report a further palindrome within one of the hr s, which was found to replicate, bringing the total to 14 palindromes. We also report imperfect palindromes, with similar 13-bp end sequences to the CpGV palindromes, within the Adoxophyes orana GV, Cryptophlebia leucotreta GV (CrleGV), Choristoneura occidentalis GV and Phthorimaea operculella GV genomes. No hr s were detected in Agrotis segetum GV, and no additional hr s or palindromes, other than those published, were detected in the Plutella xylostella GV and Xestia c-nigrum GV genomes. Several putative hr s from the GVs were tested for replication in C. pomonella cells using a CpGV-dependent replication assay. Two CrleGV hr s were found to replicate at a low level.
Archives of Virology – Springer Journals
Published: Aug 1, 2008
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