Mammalian Genome 8,583-585 (1997). e//o///e 9 Springer-Verlag New York Inc. 1997 Thomas Giinther, 1 Ralf Spiirle, 1 Klaus Schughart l'z ~GSF-National Research Center for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Ingolst~idter Landstr. 1, 85758 Oberschleif3heim, Germany 2Transgene S.A., 11 rue de Molsheim, F-67082 Strasbourg, France Received: 31 December 1996 / Accepted: 17 March 1997 The mouse open brain (opb) mutation represents an autosomal arches) may result from a primary defect of the neural tube (clo- recessive mutation with full penetrance of the phenotype. At early sure defect or malformations of a closed neural tube) or from a stages of development, homozygous mutant embryos exhibit de- failure of the somitic mesoderm to properly form dorsal vertebral fects in development of the neural tube, spinal ganglia, epaxial elements. Several mouse mutant lines have been described that can muscle, eyes, and limbs (Gtinther et al. 1994; Sp6rle et al. 1996). serve as developmental model systems for human neural tube or Here, we describe neural tube and vertebral column defects result- mesenchymal mesoderm defects, like anencephaly and/or spina ing in spina bifida at later developmental stages, and we report on bifida of the spinal cord (Copp et al. 1990). the mapping
Mammalian Genome – Springer Journals
Published: Apr 1, 2009
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