The open brain (opb) mutation maps to mouse chromosome 1

The open brain (opb) mutation maps to mouse chromosome 1 Mammalian Genome 8,583-585 (1997). e//o///e 9 Springer-Verlag New York Inc. 1997 Thomas Giinther, 1 Ralf Spiirle, 1 Klaus Schughart l'z ~GSF-National Research Center for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Ingolst~idter Landstr. 1, 85758 Oberschleif3heim, Germany 2Transgene S.A., 11 rue de Molsheim, F-67082 Strasbourg, France Received: 31 December 1996 / Accepted: 17 March 1997 The mouse open brain (opb) mutation represents an autosomal arches) may result from a primary defect of the neural tube (clo- recessive mutation with full penetrance of the phenotype. At early sure defect or malformations of a closed neural tube) or from a stages of development, homozygous mutant embryos exhibit de- failure of the somitic mesoderm to properly form dorsal vertebral fects in development of the neural tube, spinal ganglia, epaxial elements. Several mouse mutant lines have been described that can muscle, eyes, and limbs (Gtinther et al. 1994; Sp6rle et al. 1996). serve as developmental model systems for human neural tube or Here, we describe neural tube and vertebral column defects result- mesenchymal mesoderm defects, like anencephaly and/or spina ing in spina bifida at later developmental stages, and we report on bifida of the spinal cord (Copp et al. 1990). the mapping http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

The open brain (opb) mutation maps to mouse chromosome 1

Loading next page...
 
/lp/springer_journal/the-open-brain-opb-mutation-maps-to-mouse-chromosome-1-WMGDQ9KTw7
Publisher
Springer-Verlag
Copyright
Copyright © 1997 by Springer-Verlag
Subject
Life Sciences; Cell Biology; Anatomy; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900509
Publisher site
See Article on Publisher Site

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial