The noncoding RNAs: a genomic symphony of transcripts

The noncoding RNAs: a genomic symphony of transcripts Mamm Genome (2008) 19:449–453 DOI 10.1007/s00335-008-9151-8 IN TROD UCTIO N Linda D. Siracusa Æ Arthur M. Buchberg Received: 8 October 2008 / Accepted: 8 October 2008 / Published online: 15 November 2008 Springer Science+Business Media, LLC 2008 Introduction The miRNA genes Imagine you are playing a piano. Your fingers sequentially Since the first identification of miRNAs by Victor Ambros move from one end of the keyboard to the other. Now and colleagues (Lee et al. 1993), a novel mechanism for imagine there is another person, playing the same keys in controlling translation was discovered. MiRNAs are a the opposite direction. Add yet another set of hands, which group of small ncRNA molecules that are distinct from, but start and stop playing different keys within the center of the related to, small interfering RNAs (siRNAs) and that have keyboard. Now imagine the room has many pianos, each been identified in a variety of organisms (Ambros 2003; with thousands of keys, and imagine each piano with Bartel 2004; He and Hannon 2004). These small 19-24- thousands of players. The sound delicately balanced in nucleotide (nt) RNAs are transcribed as parts of longer sequence, with some melodies played very loud and others http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

The noncoding RNAs: a genomic symphony of transcripts

Loading next page...
 
/lp/springer_journal/the-noncoding-rnas-a-genomic-symphony-of-transcripts-u7uQoe7I6c
Publisher
Springer Journals
Copyright
Copyright © 2008 by Springer Science+Business Media, LLC
Subject
Life Sciences; Zoology ; Anatomy ; Cell Biology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s00335-008-9151-8
Publisher site
See Article on Publisher Site

Abstract

Mamm Genome (2008) 19:449–453 DOI 10.1007/s00335-008-9151-8 IN TROD UCTIO N Linda D. Siracusa Æ Arthur M. Buchberg Received: 8 October 2008 / Accepted: 8 October 2008 / Published online: 15 November 2008 Springer Science+Business Media, LLC 2008 Introduction The miRNA genes Imagine you are playing a piano. Your fingers sequentially Since the first identification of miRNAs by Victor Ambros move from one end of the keyboard to the other. Now and colleagues (Lee et al. 1993), a novel mechanism for imagine there is another person, playing the same keys in controlling translation was discovered. MiRNAs are a the opposite direction. Add yet another set of hands, which group of small ncRNA molecules that are distinct from, but start and stop playing different keys within the center of the related to, small interfering RNAs (siRNAs) and that have keyboard. Now imagine the room has many pianos, each been identified in a variety of organisms (Ambros 2003; with thousands of keys, and imagine each piano with Bartel 2004; He and Hannon 2004). These small 19-24- thousands of players. The sound delicately balanced in nucleotide (nt) RNAs are transcribed as parts of longer sequence, with some melodies played very loud and others

Journal

Mammalian GenomeSpringer Journals

Published: Nov 15, 2008

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off