Mamm Genome (2008) 19:449–453 DOI 10.1007/s00335-008-9151-8 IN TROD UCTIO N Linda D. Siracusa Æ Arthur M. Buchberg Received: 8 October 2008 / Accepted: 8 October 2008 / Published online: 15 November 2008 Springer Science+Business Media, LLC 2008 Introduction The miRNA genes Imagine you are playing a piano. Your ﬁngers sequentially Since the ﬁrst identiﬁcation of miRNAs by Victor Ambros move from one end of the keyboard to the other. Now and colleagues (Lee et al. 1993), a novel mechanism for imagine there is another person, playing the same keys in controlling translation was discovered. MiRNAs are a the opposite direction. Add yet another set of hands, which group of small ncRNA molecules that are distinct from, but start and stop playing different keys within the center of the related to, small interfering RNAs (siRNAs) and that have keyboard. Now imagine the room has many pianos, each been identiﬁed in a variety of organisms (Ambros 2003; with thousands of keys, and imagine each piano with Bartel 2004; He and Hannon 2004). These small 19-24- thousands of players. The sound delicately balanced in nucleotide (nt) RNAs are transcribed as parts of longer sequence, with some melodies played very loud and others
Mammalian Genome – Springer Journals
Published: Nov 15, 2008
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