European Journal of Clinical Pharmacology (2018) 74:1361–1362 https://doi.org/10.1007/s00228-018-2492-7 LETTER TO THE EDITOR The nocebo effect and patient perceptions of biosimilars in inflammatory bowel disease 1 2 3 4 1,4 4 David Pineles & Lisa Malter & Peter S. Liang & Amy Arsuaga & Brian Bosworth & David P. Hudesman & Shannon Chang Received: 29 April 2018 / Accepted: 22 May 2018 / Published online: 31 May 2018 Springer-Verlag GmbH Germany, part of Springer Nature 2018 We read with great interest a recent paper by Boone et al. . penetration into our marketplace has only recently accelerated. In this 1-year observational study, the authors sought to quan- As such, we recently performed a small, prospective study tify the nocebo rate in individuals with an immune-mediated aimed at gauging IBD patients’ initial perceptions of inflammatory disease who were switched from the originator biosimilars. In 2017, we surveyed 132 adult patients with infliximab to a biosimilar for a non-medical reason. Patients IBD at two university-affiliated gastroenterology clinics regard- were provided informed consent and voluntarily agreed to ing their current impression of biosimilars. A standardized cov- transition to the infliximab biosimilar. The patients in this er sheet was included with the 14-question survey
European Journal of Clinical Pharmacology – Springer Journals
Published: May 31, 2018
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