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AE Green, MR Munafo, CG DeYoung, JA Fossella, J Fan, JR Gray (2008)
Using genetic data in cognitive neuroscience: from growing pains to genuine insightsNat Rev Neurosci, 9
JJ Barnes, AJ Dean, LS Nandam, RG O’Connell, MA Bellgrove (2011)
The molecular genetics of executive function: role of monoamine system genesBiol Psychiatry, 69
ES Gershon, LR Goldin (1986)
Clinical methods in psychiatric genetics. I. Robustness of genetic marker investigative strategiesActa Psychiatr Scand, 74
E Congdon, RA Poldrack, NB Freimer (2010)
Neurocognitive phenotypes and genetic dissection of disorders of brain and behaviorNeuron, 68
TR Insel (2007)
From animal models to model animalsBiol Psychiatry, 62
K MacCorquodale, PE Meehl (1948)
On a distinction between hypothetical constructs and intervening variablesPsychol Rev, 55
RM Bilder, A Howe, N Novak, FW Sabb, DS Parker (2011)
The genetics of cognitive impairment in schizophrenia: a phenomic perspectiveTrends Cogn Sci, 15
(2013)
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysisLancet, 381
R Plomin, CM Haworth, OS Davis (2009)
Common disorders are quantitative traitsNat Rev Genet, 10
MR Milad, SL Rauch, RK Pitman, GJ Quirk (2006)
Fear extinction in rats: implications for human brain imaging and anxiety disordersBiol Psychol, 73
LM Shin, I Liberzon (2010)
The neurocircuitry of fear, stress, and anxiety disordersNeuropsychopharmacology, 35
II Gottesman, TD Gould (2003)
The endophenotype concept in psychiatry: etymology and strategic intentionsAm J Psychiatry, 160
SJ Sanders, MT Murtha, AR Gupta, JD Murdoch, MJ Raubeson, AJ Willsey, AG Ercan-Sencicek, NM DiLullo, NN Parikshak, JL Stein, MF Walker, GT Ober, NA Teran, Y Song, P El-Fishawy, RC Murtha, M Choi, JD Overton, RD Bjornson, NJ Carriero, KA Meyer, K Bilguvar, SM Mane, N Sestan, RP Lifton, M Gunel, K Roeder, DH Geschwind, B Devlin, MW State (2012)
De novo mutations revealed by whole-exome sequencing are strongly associated with autismNature, 485
(2013)
Diagnostic and statistical manual of mental disorders
Heterogeneity of disorders, comorbidity across diagnoses, and reification of existing disease classifications are some of the challenges facing psychiatry in the twenty-first century. NIMH’s Research Domain Criteria (RDoC) Project seeks to address these issues by defining basic dimensions of function that cut across disorders as traditionally defined and can be studied across multiple units of analysis, from genes to neural circuits to behaviors. The intent is to translate rapid progress in basic genetic, neurobiological, and behavioral research to an improved integrative understanding of psychopathology. In so doing, RDoC seeks to facilitate the development of new and/or optimally targeted treatments for mental disorders. The RDoC project would not have been possible without NIMH’s long-term investment in basic research. Without the continuation of basic research, both related and unrelated to current RDoC domains and constructs, it will not be possible to sustain the RDoC effort. This article seeks to outline the relationship between RDoC and NIMH’s ongoing support for broad-based basic research, from genetics to behavior.
Mammalian Genome – Springer Journals
Published: Oct 2, 2013
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