Review Incorporating Mouse Genome Mammalian Genome 9, 417–418 (1998). © Springer-Verlag New York Inc. 1998 Lorraine Flaherty, Bruce Herron Molecular Genetics Program and Laboratory of Developmental Genetics, Wadsworth Center, P.O. Box 22002, 120 New Scotland Avenue, Albany, New York 12201-2002, USA Received: 27 January 1998 / Accepted: 3 February 1998 When you are in the middle of a positional cloning project and up Elliott and coworkers (1997) noted some bias in the retention of th to your 1000 backcross mouse and still do not have the needed the most proximal marker on Chromosome (Chr) 13. recombinant in your critical region.... or if you clone a fragment So far, approximately 400 markers have been placed on this off a YAC and wonder whether it is linked to your locus of interest panel. Linkage groups have also been constructed on the basis of but can’t find a polymorphism between strains, what do you do? a LOD score of 4.0. From available data, there are multiple linkage Try the new mouse radiation hybrid panel now available to the groups per chromosome with many gaps (McCarthy et al. 1997); mouse community. This hybrid panel was produced by McCarthy however, as the number of
Mammalian Genome – Springer Journals
Published: Jun 1, 1998
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