Mammalian Genome 10, 1030–1031 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 The neurobeachin gene (Nbea) identifies a new region of homology between mouse central Chromosome 3 and human Chromosome 13q13 1 2 3 2 1 1 Debra J. Gilbert, Hartmut Engel, Xiaolu Wang, Karl-Heinz Grzeschik, Neal G. Copeland, Nancy A. Jenkins, Manfred W. Kilimann Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA Abteilung fu ¨ r Allgemeine Humangenetik, Fachbereich Medizin, Philipps-Universita ¨t Marburg, D-35037 Marburg, Germany Institut fu ¨ r Physiologische Chemie, Ruhr-Universita ¨t Bochum, D-44780 Bochum, Germany Received: 25 March 1999 / Accepted: 8 June 1999 Neurobeachin is a newly identified, brain-specific 327-kDa cyto- are: centromere–Fgf2–34/178–Nbea–1/141–Mme–9/141–Fgg. solic protein that is peripherally associated with several membrane The recombination frequencies [expressed as genetic distances in compartments including trans-Golgi network- and endosome-like centimorgans (cM) ± the standard error] are: Fgf2–19.1 ± 3.0– structures. It contains a BEACH domain, a highly conserved se- Nbea–0.7 ± 0.7–Mme–6.4 ± 2.1–Fgg. Gene localization was con- quence module of ~ 280 amino acids and unknown function that it firmed with a second probe of 883 bp from the 38-untranslated shares with at least 10 distinct
Mammalian Genome – Springer Journals
Published: Oct 1, 1999
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