The nematode Caenorhabditis elegans as a model to study viruses

The nematode Caenorhabditis elegans as a model to study viruses Caenorhabditis elegans is a worm that has been extensively studied, and it is today an accepted model in many different biological fields. C. elegans is cheap to maintain, it is transparent, allowing easy localization studies, and it develops from egg to adult in around 4 days. Many mutants, available to the scientific community, have been developed. This has facilitated the study of the role of particular genes in many cellular pathways, which are highly conserved when compared with higher eukaryotes. This review describes the advantages of C. elegans as a laboratory model and the known mechanisms utilized by this worm to fight pathogens. In particular, we describe the strong C. elegans RNAi machinery, which plays an important role in the antiviral response. This has been shown in vitro ( C. elegans cell cultures) as well as in vivo (RNAi-deficient strains) utilizing recently described viruses that have the worm as a host. Infections with mammalian viruses have also been achieved using chemical treatment. The role of viral genes involved in pathogenesis has been addressed by evaluating the phenotypes of transgenic strains of C. elegans expressing those genes. Very simple approaches such as feeding the worm with bacteria transformed with viral genes have also been utilized. The advantages and limitations of different approaches are discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

The nematode Caenorhabditis elegans as a model to study viruses

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Publisher
Springer Vienna
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-014-2168-2
Publisher site
See Article on Publisher Site

References

  • A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes
    Culetto, E; Sattelle, DB
  • Caenorhabditis elegans : a model genetic host to study Pseudomonas aeruginosa pathogenesis
    Tan, MW; Ausubel, FM
  • A conserved toll-like receptor is required for Caenorhabditis elegans innate immunity
    Tenor, JL; Aballay, A
  • Glycosylation genes expressed in seam cells determine complex surface properties and bacterial adhesion to the cuticle of Caenorhabditis elegans
    Gravato-Nobre, MJ; Stroud, D; O’Rourke, D; Darby, C; Hodgkin, J
  • RNAi pathways in the recognition of foreign RNA: antiviral responses and host-parasite interactions in nematodes
    Sarkies, P; Miska, EA

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