Mammalian Genome 11, 478–483 (2000). DOI: 10.1007/s003350010093 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 J.K. Noveroske,* J.S. Weber,* M.J. Justice Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA Received: 16 December 1999 / Accepted: 16 December 1999 Introduction four times higher than in bone marrow and six times higher than in germ cells (van Zeeland et al. 1990). These differences can be attributed to variations in the efficiency of DNA repair systems as N-ethyl-N-nitrosourea (ENU) has become one of the most power- well as the alternative environments of tissue-specific metabolic ful tools in mammalian genetics. It has the highest mutation rate of processes. To further complicate the measurement of lesion rates, any germline mutagen tested in the mouse, allowing phenotype- multiple cell types within a given organ likely express multiple driven approaches to isolate mutations in any gene of interest. Its repair systems at different levels (Vogel and Natarajan 1995). As ability to produce single base pair mutations in vivo allows for a detailed analysis of a gene’s normal functions and the physiologi- a consequence of tissue and cell-specific variability, valuable data cal consequences when mutated, making it
Mammalian Genome – Springer Journals
Published: Feb 25, 2014
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