Mammalian Genome 12, 175–176 (2001). DOI: 10.1007/s003350010255 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2001 The murine type 1 diabetes loci, Idd1, Idd3, Idd5, Idd9, and − − + Idd17/10/18, do not control thymic CD4 CD8 /TCRab deficiency in the nonobese diabetic mouse 1 1 1 2 2 1 Christopher J. Lord, Sarah Howlett, Paul A. Lyons, Laurence B. Peterson, Linda S. Wicker, John A. Todd Department of Medical Genetics, The Wellcome Trust Centre for Molecular Mechanisms in Disease, University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2XY, UK Department of Immunology and Rheumatology, Merck Research Laboratories, Rahway, NJ, USA Department of Pharmacology, Merck Research Laboratories, Rahway, NJ, USA Received: 31 July 2000 / Accepted: 13 October 2000 Over the past 12 years our laboratories have localized the poly- genic genetic loci (known as Idd loci) that predispose to autoim- mune type 1 diabetes in the Nonobese Diabetic (NOD) mouse. To achieve this, we have developed over 80 congenic strains that possess a NOD genome except for a specific chromosome region (a congenic interval) derived from a diabetes-resistant strain (nor- mally either C57BL/6 or C57BL/10). A reduction in diabetes fre- quency (compared with a NOD cohort) in
Mammalian Genome – Springer Journals
Published: Feb 1, 2001
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