Mammalian Genome 11, 402–404 (2000). Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Kip1 The murine gene Cdkn1b (p27 ) maps to distal Chromosome 6 and is excluded as Pas1 Christopher J. Kemp, Kyung-Hoon Kim, Jeannette Philipp Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., Seattle, Washington 98109, USA Received: 13 August 1999 / Accepted: 11 January 2000 Activation of cyclin-dependent kinase-2 (cdk2) by cyclin E is a D6Mit220. Thus, the murine Cdkn1b gene maps to distal Chro- key event in driving cells from G1 into S phase of the cell cycle. mosome (Chr) 6 as shown in Fig. 1. Kip1 Cdkn1b, also known as p27 or p27, belongs to the Kip/Cip The human p27/Kip1 gene maps to Chr 12p13 (Pietenpol et al. family of cdk inhibitors and responds to extracellular signals such 1995). There is a large region of conserved gene order between as TGFB and cell contact by binding to cyclin E/cdk2 complexes human 12p12-12p13 and murine Chr 6 (see Fig. 1), and thus (Polyak et al. 1994). This binding inhibits cdk2 activation and Cdkn1b/p27/Kip1 is added to the list of genes in this grouping. thereby blocks cells from entering S phase. Cdkn1b also binds
Mammalian Genome – Springer Journals
Published: May 1, 2000
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