Mammalian Genome 9, 907–909 (1998). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1998 The mouse tight skin (Tsk) phenotype is not dependent on the presence of mature T and B lymphocytes 1 2 1 2 Linda D. Siracusa, Rodney McGrath, Jill K. Fisher, Sergio A. Jimenez Department of Microbiology and Immunology, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, 233 South 10th Street, Philadelphia, Pennsylvania 19107-5541, USA Department of Rheumatology, Jefferson Medical College, Thomas Jefferson University, 233 South 10th Street, Philadelphia, Pennsylvania 19107-5541, USA Received: 2 February 1998 / Accepted: 30 June 1998 The mouse tight skin (Tsk) mutation occurred spontaneously in the beads and longer than normal periodicity. The relationship of this inbred strain B10.D2(58N)/Sn (Green et al. 1976). Heterozygous novel mutant form of the Fbn1 glycoprotein to the Tsk phenotype Tsk mice have thickened skin that is firmly bound to the subcuta- is currently under investigation. neous and deep muscular tissues; Tsk/+ skin lacks the pliability The presence of fibrosis has been noted in various organs of and elasticity of normal skin. Excessive accumulation of certain the Tsk/+ mouse including skin, heart, lung, bladder, and kidney collagens and glycosaminoglycans has been detected in several (Jimenez
Mammalian Genome – Springer Journals
Published: Nov 1, 1998
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